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- W138072033 abstract "Gap junctional plaques were found between androgen-sensitive motoneurons of the spinal nucleus of the bulbocavrnosus (SNB) of adult male rats, using ultrastructural techniques. The number and length of gap junctional plaques were examined in these cells. As for in situ hybridization studies, cDNA encoding rat liver gap junction protein (connexin 32) was used to detect gap junction mRNA in the SNB motoneurons of adult male rats. Removal of androgen by castration significantly reduced the expression level of gap junction mRNA and the number and length of gap junctional plaques in the SNB motoneurons, whereas these changes were prevented by testosterone treatment. On the contrary, castration or testosterone treatment did not induce any changes in the expression level of gap junction mRNA and the number and length of gap junctional plaques in the androgeninsensitive motoneurons of the retrodorsolateral nucleus. These results suggest that androgen regulates the expression of gap junction gene and the formation of gap junction channels in the SNB motoneurons, and may provide evidence for the androgenic regulation of degree of coupling between SNB motoneurons which may allow for the synchronization of metabolic and/or electrical activity in the SNB." @default.
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- W138072033 date "1995-01-01" @default.
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- W138072033 title "Androgen regulates expression of gap junction gene in androgen-sensitive motoneurons" @default.
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- W138072033 doi "https://doi.org/10.1016/b978-0-444-81929-1.50052-6" @default.
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