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- W138181543 abstract "A simulation study of transport and utilization of glucose in brain tissue is presented in relation to the sue of Positron Emission Tomography (PET) with healthy and diseased subjects. A physiologically-based, comprehensive compartmental model including recirculation and peripheral distribution of labeled glucose is developed, and the system of equations solved numerically for various sets of values of the rate constants: k{sub 1}, k{sub 2} and k{sub 3}. Comparison between experimental curves and curves simulated with the model suggests that a decrease in k{sub 3} may be the main reason for the impaired uptake of glucose in subjects with Alzheimer's disease. Simulated experimental data generated by the comprehensive model were fitted by nonlinear regression to a two-compartment model with a step-infusion input. The fitted rate constants k{sub 1} and k{sub 2} were shown to be 30 to 50% different from the theoretical ones, whereas their ratio remained essentially invariant. On the other hand, k{sub 3} values showed departures in the range of 5 to 20%. It is concluded that the application of the constant infusion model to PET may allow obtaining useful information with respect to the steps of brain glucose uptake in health and disease. Correct estimation of absolute valuesmore » of the transport constants k{sub 1} and k{sub 2}, however, may require the use of a distributed model and short time, one pass experiments.« less" @default.
- W138181543 created "2016-06-24" @default.
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- W138181543 date "1990-02-26" @default.
- W138181543 modified "2023-09-23" @default.
- W138181543 title "Modeling glucose uptake in the brain for positron emission tomography" @default.
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