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- W138183834 abstract "Ameloblastoma is a rare, benign oral tumour. Tumours develop within the jaw bone and are highly destructive and invasive, with cells migrating into the jaw and surrounding soft tissue. This is a little-understood disease which if left untreated causes dramatic bone destruction and maxillofacial disfigurement. Current treatment is radical surgery, often resulting in extensive loss of function and tissue. An ameloblastoma-derived cell line, AM-1, has been established [1]. Cells were isolated from a human tumour and immortalised by the addition of HPV-16 DNA. This study aims to (i) make a 3D in vitro ameloblastoma disease model, using plastic-compressed collagen gel [2] seeded with AM-1 cells, and (ii) use this bone construct to characterise tissue remodelling, cell growth and invasiveness." @default.
- W138183834 created "2016-06-24" @default.
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- W138183834 date "2011-07-01" @default.
- W138183834 modified "2023-09-27" @default.
- W138183834 title "In vitro 3D tissue modelling: Insights into ameloblastoma pathogenesis" @default.
- W138183834 hasPublicationYear "2011" @default.
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