Matches in SemOpenAlex for { <https://semopenalex.org/work/W138315093> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W138315093 abstract "Apolipoproteins are major determinants of plasma lipoprotein-lipid distribution. Dyslipidemia with elevated level of low-density lipoprotein cholesterol (LDL-C) and decreased level of high-density lipoprotein cholesterol (HDL-C) is associated with increased risk of cardiovascular disease (CVD), which is a major public health problem worldwide. Therefore, unraveling the genetic basis of plasma lipoprotein-lipid traits would provide insight into risk prediction and contribute to the developing of new therapeutic and intervention measures to reduce the CVD burden, which has a public health importance. The objective of this study was to characterize genetic variation in the APOE-C1-C4-C2 gene cluster on chromosome 19q13.32 by resequencing selected individuals from non-Hispanic White (NHW) and African Black populations with extreme lipid profile and then genotyping the identified sequence variants (common tagSNPs and rare variants) along with the HapMap tagSNPs covering the intergenic regions in the entire datasets (623 NHWs, and 788 Blacks) to evaluate their association with major lipid traits. Sequencing of the four apolipoprotein genes along with their hepatic control regions in subjects falling in the upper (47 NHWs, 48 Blacks), and lower (48 NHWs, 47 Blacks) 10th percentile distribution of HDL-C/triglycerides (TG) revealed 230 variants (215 substitution, 15 indels), of which 63 were shared in both populations, 52 were NHW-specific and 115 were Black-specific. A total of 70 variants (65 sequencing-identified, 5 HapMap tagSNPs) in NHWs and 108 variants (103 sequencing-identified, 5 HapMap tagSNPs) in Blacks were successfully genotyped in the entire datasets and were considered for the association analyses. Twenty variants in NHWs and twenty-four variants in Blacks (MAF>1%) showed nominally significant association (P<0.05) with at least one lipid trait. Although the major contribution of the APOE-C1-C4-C2 gene cluster was on LDL-C and apolipoprotein (apo) B, we observed multiple associations with other lipid traits, including TG, HDL-C, and apoA1. In addition to the significant contribution of common variants, rare/less common variants showed significant association with lipid traits. Our findings confirm the significant contribution of APOE-C1-C4-C2 genetic variation in affecting plasma lipid profile in the general population and consequently the CVD risk." @default.
- W138315093 created "2016-06-24" @default.
- W138315093 creator A5003599736 @default.
- W138315093 creator A5008781173 @default.
- W138315093 creator A5020755687 @default.
- W138315093 creator A5034858211 @default.
- W138315093 creator A5035545992 @default.
- W138315093 creator A5036982595 @default.
- W138315093 creator A5052349035 @default.
- W138315093 creator A5053755396 @default.
- W138315093 creator A5058431944 @default.
- W138315093 creator A5072699552 @default.
- W138315093 creator A5078651121 @default.
- W138315093 creator A5091812680 @default.
- W138315093 date "2017-08-01" @default.
- W138315093 modified "2023-09-27" @default.
- W138315093 title "A comprehensive association study of apolipoprotein E-C1-C4-C2 gene cluster variation with plasma lipoprotein traits" @default.
- W138315093 doi "https://doi.org/10.1016/j.atherosclerosis.2017.06.270" @default.
- W138315093 hasPublicationYear "2017" @default.
- W138315093 type Work @default.
- W138315093 sameAs 138315093 @default.
- W138315093 citedByCount "0" @default.
- W138315093 crossrefType "journal-article" @default.
- W138315093 hasAuthorship W138315093A5003599736 @default.
- W138315093 hasAuthorship W138315093A5008781173 @default.
- W138315093 hasAuthorship W138315093A5020755687 @default.
- W138315093 hasAuthorship W138315093A5034858211 @default.
- W138315093 hasAuthorship W138315093A5035545992 @default.
- W138315093 hasAuthorship W138315093A5036982595 @default.
- W138315093 hasAuthorship W138315093A5052349035 @default.
- W138315093 hasAuthorship W138315093A5053755396 @default.
- W138315093 hasAuthorship W138315093A5058431944 @default.
- W138315093 hasAuthorship W138315093A5072699552 @default.
- W138315093 hasAuthorship W138315093A5078651121 @default.
- W138315093 hasAuthorship W138315093A5091812680 @default.
- W138315093 hasConcept C104317684 @default.
- W138315093 hasConcept C177580304 @default.
- W138315093 hasConcept C180754005 @default.
- W138315093 hasConcept C197754878 @default.
- W138315093 hasConcept C54355233 @default.
- W138315093 hasConcept C68873052 @default.
- W138315093 hasConcept C86803240 @default.
- W138315093 hasConceptScore W138315093C104317684 @default.
- W138315093 hasConceptScore W138315093C177580304 @default.
- W138315093 hasConceptScore W138315093C180754005 @default.
- W138315093 hasConceptScore W138315093C197754878 @default.
- W138315093 hasConceptScore W138315093C54355233 @default.
- W138315093 hasConceptScore W138315093C68873052 @default.
- W138315093 hasConceptScore W138315093C86803240 @default.
- W138315093 hasLocation W1383150931 @default.
- W138315093 hasOpenAccess W138315093 @default.
- W138315093 hasPrimaryLocation W1383150931 @default.
- W138315093 hasRelatedWork W2001844995 @default.
- W138315093 hasRelatedWork W2008461976 @default.
- W138315093 hasRelatedWork W2023582909 @default.
- W138315093 hasRelatedWork W2036691589 @default.
- W138315093 hasRelatedWork W2043261575 @default.
- W138315093 hasRelatedWork W2104177528 @default.
- W138315093 hasRelatedWork W2111843440 @default.
- W138315093 hasRelatedWork W2127913838 @default.
- W138315093 hasRelatedWork W2145140481 @default.
- W138315093 hasRelatedWork W2152528457 @default.
- W138315093 hasRelatedWork W2160138207 @default.
- W138315093 hasRelatedWork W2610682429 @default.
- W138315093 hasRelatedWork W2626644053 @default.
- W138315093 hasRelatedWork W2803813398 @default.
- W138315093 hasRelatedWork W2806910646 @default.
- W138315093 hasRelatedWork W2925075106 @default.
- W138315093 hasRelatedWork W2953315029 @default.
- W138315093 hasRelatedWork W3004044579 @default.
- W138315093 hasRelatedWork W3119543092 @default.
- W138315093 hasRelatedWork W600372571 @default.
- W138315093 isParatext "false" @default.
- W138315093 isRetracted "false" @default.
- W138315093 magId "138315093" @default.
- W138315093 workType "article" @default.