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- W138320 abstract "e18055 Background: There is limited information on the impact of race and ethnicity on clinical outcomes and resource utilization during lung cancer treatment. This prospective, observational study is evaluating the impact of ethnicity on disease control rate (DCR) in patients (pts) with NSCLC treated with P in the second-line setting. Methods: Eligibility criteria include stage IIIB or IV NSCLC pts receiving single-agent P for second-line therapy in routine clinical practice. This report describes observations from an early examination of the data of pts from 4 different ethnic origins: Caucasian (C), African (AA), Asian (A), and Hispanic (H). DCR was defined as the rate of complete response (CR) + partial response (PR) + stable disease (SD). Noninferiority of minority patients to C will be concluded if the confidence interval (CI) upper limit of the estimated mean DCR difference is less than 0.14. Results: See Table. Conclusions: Race/ethnicity was associated with differences in baseline characteristics (age, gender, education level, marital status, income, private insurance, and smoking status) that may influence clinical outcomes and resource utilization in the second-line treatment of advanced NSCLC with P. Although the estimates for DCR are similar for each of the ethnic groups, the CIs are not yet sufficiently narrow to formally declare non-inferiority at the prespecified level. Additional data are needed to establish a definitive conclusion. C (N = 305) AA (N = 57) A (N = 27) H (N = 14) P value (C vs. AA) Mean age, yrs 66 63 65 61 0.02 Male, % 53 68 44 57 0.03 Adenocarcinoma, % 63 67 85 79 0.53 Prior surgery, % 30 18 22 50 0.06 Current smoker, % 26 39 0 21 0.06 ECOG PS of 0 or 1, % 78 88 90 83 0.14 Income ≤$25,000, % 28 51 22 36 0.0001 Private health insurance, % 49 29 33 33 0.03 Married, % 62 40 63 43 0.01 Some college, % 40 26 41 36 <0.05 DCR, % 40 41 71 22 − Mean DCR difference, % (CI upper limit of DCR) Ref (NA) −0.03 (0.30) −0.34 (0.19) 0.11 (0.44) − PFS, mos (95% CI) 2.6 (2.3, 3.0) 3.1 (1.9, 3.8) 3.9 (1.8, NE) 2.3 (1.9, 3.7) 0.8 OS, mos (95% CI) 5.9 (5.1, 6.8) 7.8 (3.6, 12.5) NE (1.8, NE) NE (NE, NE) 0.7 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Lilly Lilly Lilly" @default.
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- W138320 date "2010-05-20" @default.
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- W138320 title "Interim results of an observational study evaluating the impact of ethnic origin on the effect of second-line treatment with pemetrexed (P) for advanced non-small cell lung cancer (NSCLC)." @default.
- W138320 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.e18055" @default.
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