Matches in SemOpenAlex for { <https://semopenalex.org/work/W138329689> ?p ?o ?g. }
- W138329689 abstract "Heterogeneity within the cell population is a feature of many tumors. This lack of cellular homogeneity may originate from a number of sources, including differential nutrient status due to the de novo microcirculations of tumors, to infiltration of normal cells into the tumor, and to the hierarchical natures of the cell populations from which cancers arise. Tumors are thought to arise from one or more tumor initiating cells (TIC) within the population and to found hierarchies of progenitors and more differentiated cancer cells. TIC are often derived from tissue stem cells and these cancer stem cells are characterized by resistance to most cytotoxic treatments and by a high metastatic rate. Many of the properties of tumor populations, including the ability to express mutated oncogenes and to evolve new features such as treatment resistance and invasive and metastatic potential appear to depend on the molecular chaperone Hsp90. We discuss the potential of targeting the heterogeneous cell population with Hsp90 inhibitory drugs and its potential ability to inactivate TIC and to block the evolution of new phenotypes in cancer." @default.
- W138329689 created "2016-06-24" @default.
- W138329689 creator A5018799755 @default.
- W138329689 date "2013-03-01" @default.
- W138329689 modified "2023-09-24" @default.
- W138329689 title "Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy." @default.
- W138329689 cites W1501009914 @default.
- W138329689 cites W1554180547 @default.
- W138329689 cites W1969768379 @default.
- W138329689 cites W1972642182 @default.
- W138329689 cites W1979592611 @default.
- W138329689 cites W1981689158 @default.
- W138329689 cites W1982245104 @default.
- W138329689 cites W1988760251 @default.
- W138329689 cites W1991771669 @default.
- W138329689 cites W1992909271 @default.
- W138329689 cites W1998002050 @default.
- W138329689 cites W2000929246 @default.
- W138329689 cites W2004792969 @default.
- W138329689 cites W2007834458 @default.
- W138329689 cites W2011077041 @default.
- W138329689 cites W2012172048 @default.
- W138329689 cites W2015981241 @default.
- W138329689 cites W2018028199 @default.
- W138329689 cites W2018792466 @default.
- W138329689 cites W2021303201 @default.
- W138329689 cites W2022531767 @default.
- W138329689 cites W2023316892 @default.
- W138329689 cites W2023560061 @default.
- W138329689 cites W2027045360 @default.
- W138329689 cites W2029741513 @default.
- W138329689 cites W2041686632 @default.
- W138329689 cites W2042070921 @default.
- W138329689 cites W2042198997 @default.
- W138329689 cites W2044173055 @default.
- W138329689 cites W2044858560 @default.
- W138329689 cites W2044905529 @default.
- W138329689 cites W2049491375 @default.
- W138329689 cites W2053356355 @default.
- W138329689 cites W2057507711 @default.
- W138329689 cites W2060902443 @default.
- W138329689 cites W2072088409 @default.
- W138329689 cites W2072451938 @default.
- W138329689 cites W2074730941 @default.
- W138329689 cites W2077661681 @default.
- W138329689 cites W2084371510 @default.
- W138329689 cites W2086439107 @default.
- W138329689 cites W2088703187 @default.
- W138329689 cites W2091772830 @default.
- W138329689 cites W2097862336 @default.
- W138329689 cites W2102085111 @default.
- W138329689 cites W2102144390 @default.
- W138329689 cites W2102265655 @default.
- W138329689 cites W2117692326 @default.
- W138329689 cites W2124218468 @default.
- W138329689 cites W2127617517 @default.
- W138329689 cites W2131507207 @default.
- W138329689 cites W2139477237 @default.
- W138329689 cites W2140594007 @default.
- W138329689 cites W2150437708 @default.
- W138329689 cites W2162994439 @default.
- W138329689 cites W2170975933 @default.
- W138329689 cites W2171427413 @default.
- W138329689 cites W2410095871 @default.
- W138329689 cites W2007340367 @default.
- W138329689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4083486" @default.
- W138329689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23545047" @default.
- W138329689 hasPublicationYear "2013" @default.
- W138329689 type Work @default.
- W138329689 sameAs 138329689 @default.
- W138329689 citedByCount "20" @default.
- W138329689 countsByYear W1383296892014 @default.
- W138329689 countsByYear W1383296892015 @default.
- W138329689 countsByYear W1383296892016 @default.
- W138329689 countsByYear W1383296892017 @default.
- W138329689 countsByYear W1383296892018 @default.
- W138329689 countsByYear W1383296892019 @default.
- W138329689 countsByYear W1383296892023 @default.
- W138329689 crossrefType "journal-article" @default.
- W138329689 hasAuthorship W138329689A5018799755 @default.
- W138329689 hasConcept C104317684 @default.
- W138329689 hasConcept C113968399 @default.
- W138329689 hasConcept C121332964 @default.
- W138329689 hasConcept C121608353 @default.
- W138329689 hasConcept C127716648 @default.
- W138329689 hasConcept C1491633281 @default.
- W138329689 hasConcept C153400128 @default.
- W138329689 hasConcept C154317977 @default.
- W138329689 hasConcept C201750760 @default.
- W138329689 hasConcept C202751555 @default.
- W138329689 hasConcept C2777306565 @default.
- W138329689 hasConcept C2778287671 @default.
- W138329689 hasConcept C2779013556 @default.
- W138329689 hasConcept C28328180 @default.
- W138329689 hasConcept C2908647359 @default.
- W138329689 hasConcept C502942594 @default.
- W138329689 hasConcept C54355233 @default.
- W138329689 hasConcept C55427017 @default.
- W138329689 hasConcept C64618202 @default.
- W138329689 hasConcept C71924100 @default.