Matches in SemOpenAlex for { <https://semopenalex.org/work/W138434982> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W138434982 abstract "Hydrophobic, proteolipid-like protein of Mr 6500 was isolated from ether/ethanol extracts of human, canine and bovine pulmonary surfactant. Amino acid composition of the protein demonstrated a remarkable abundance of hydrophobic residues, particularly valine and leucine. The N-terminal amino acid sequence of the human protein was determined: N-Leu-Ile-Pro-Cys-Cys-Pro-Val-Asn-Leu-Lys-Arg-Leu-Leu-Ile-Val4... An oligonucleotide probe was used to screen an adult human lung cDNA library and resulted in detection of cDNA clones with predicted amino acid sequence with close identity to the N-terminal amino acid sequence of the human peptide. SPL(pVal) was found within the reading frame of a larger peptide. SPL(pVal) results from proteolytic processing of a larger preprotein. Northern blot analysis detected in a single 1.0 kilobase SPL(pVal) RNA which was less abundant in fetal than in adult lung. Mixtures of purified canine and bovine SPL(pVal) and synthetic phospholipids display properties of rapid adsorption and surface tension lowering activity characteristic of surfactant. Human SPL(pVal) is a pulmonary surfactant proteolipid which may therefore be useful in combination with phospholipids and/or other surfactant proteins for the treatment of surfactant deficiency such as hyaline membrane disease in newborn infants." @default.
- W138434982 created "2016-06-24" @default.
- W138434982 creator A5000522398 @default.
- W138434982 creator A5021348937 @default.
- W138434982 creator A5028739100 @default.
- W138434982 creator A5031234530 @default.
- W138434982 creator A5044003407 @default.
- W138434982 creator A5047675365 @default.
- W138434982 creator A5054725734 @default.
- W138434982 creator A5091015970 @default.
- W138434982 date "1987-05-01" @default.
- W138434982 modified "2023-10-17" @default.
- W138434982 title "Deduced amino acid sequence of human pulmonary surfactant proteolipid: SPL(pVal)" @default.
- W138434982 hasPublicationYear "1987" @default.
- W138434982 type Work @default.
- W138434982 sameAs 138434982 @default.
- W138434982 citedByCount "0" @default.
- W138434982 crossrefType "journal-article" @default.
- W138434982 hasAuthorship W138434982A5000522398 @default.
- W138434982 hasAuthorship W138434982A5021348937 @default.
- W138434982 hasAuthorship W138434982A5028739100 @default.
- W138434982 hasAuthorship W138434982A5031234530 @default.
- W138434982 hasAuthorship W138434982A5044003407 @default.
- W138434982 hasAuthorship W138434982A5047675365 @default.
- W138434982 hasAuthorship W138434982A5054725734 @default.
- W138434982 hasAuthorship W138434982A5091015970 @default.
- W138434982 hasConcept C104317684 @default.
- W138434982 hasConcept C153911025 @default.
- W138434982 hasConcept C167625842 @default.
- W138434982 hasConcept C185592680 @default.
- W138434982 hasConcept C187882448 @default.
- W138434982 hasConcept C2777573094 @default.
- W138434982 hasConcept C2779281246 @default.
- W138434982 hasConcept C515207424 @default.
- W138434982 hasConcept C55493867 @default.
- W138434982 hasConcept C58226133 @default.
- W138434982 hasConcept C86803240 @default.
- W138434982 hasConceptScore W138434982C104317684 @default.
- W138434982 hasConceptScore W138434982C153911025 @default.
- W138434982 hasConceptScore W138434982C167625842 @default.
- W138434982 hasConceptScore W138434982C185592680 @default.
- W138434982 hasConceptScore W138434982C187882448 @default.
- W138434982 hasConceptScore W138434982C2777573094 @default.
- W138434982 hasConceptScore W138434982C2779281246 @default.
- W138434982 hasConceptScore W138434982C515207424 @default.
- W138434982 hasConceptScore W138434982C55493867 @default.
- W138434982 hasConceptScore W138434982C58226133 @default.
- W138434982 hasConceptScore W138434982C86803240 @default.
- W138434982 hasLocation W1384349821 @default.
- W138434982 hasOpenAccess W138434982 @default.
- W138434982 hasPrimaryLocation W1384349821 @default.
- W138434982 hasRelatedWork W1270417454 @default.
- W138434982 hasRelatedWork W1490001209 @default.
- W138434982 hasRelatedWork W1602844435 @default.
- W138434982 hasRelatedWork W1764678368 @default.
- W138434982 hasRelatedWork W1964309802 @default.
- W138434982 hasRelatedWork W1965280714 @default.
- W138434982 hasRelatedWork W2007054047 @default.
- W138434982 hasRelatedWork W2011225090 @default.
- W138434982 hasRelatedWork W2058374294 @default.
- W138434982 hasRelatedWork W2061881990 @default.
- W138434982 hasRelatedWork W2063011521 @default.
- W138434982 hasRelatedWork W2071051099 @default.
- W138434982 hasRelatedWork W2071956716 @default.
- W138434982 hasRelatedWork W2080297208 @default.
- W138434982 hasRelatedWork W2086705182 @default.
- W138434982 hasRelatedWork W2090699964 @default.
- W138434982 hasRelatedWork W2176810694 @default.
- W138434982 hasRelatedWork W2339659988 @default.
- W138434982 hasRelatedWork W2404865693 @default.
- W138434982 hasRelatedWork W2587866466 @default.
- W138434982 isParatext "false" @default.
- W138434982 isRetracted "false" @default.
- W138434982 magId "138434982" @default.
- W138434982 workType "article" @default.