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• W138566699 endingPage "47" @default.
• W138566699 startingPage "27" @default.
• W138566699 abstract "Publisher Summary This chapter reviews the contributions of cryo-electron microscopy (cryo-EM) and single-particle three-dimensional reconstruction (3D cryo-EM) to understanding the structural architecture of ryanodine receptors (RyRs). 3D reconstructions at about 1-nm resolution are determined for RyRs in putatively open and closed states, and reveal the mechanism of calcium release channel gating and of allosteric communication over distance greater than 10 nm between the cytoplasmic and transmembrane (TM) regions of the receptor. The information content of 3D cryo-EM is greatly increased when combined with biochemical and molecular biological labeling and strategies for docking atomic structures of subcomponents into cryo-EM density maps or RyRs. All three of the mammalian isoforms—RyR1, RyR2, RyR3—have been characterized by cryo-EM and 3D reconstruction and based on their high-sequence similarity, shown to have nearly identical 3D structures. Once initial 3D reconstructions of RyRs became available, it was quite easy to determine additional reconstructions at moderate resolutions of RyRs that have been chemically modified by various ligands, mainly for the purpose of determining the locations of the ligands." @default.
• W138566699 created "2016-06-24" @default.
• W138566699 creator A5002302629 @default.
• W138566699 creator A5065771969 @default.
• W138566699 date "2010-01-01" @default.
• W138566699 modified "2023-10-16" @default.
• W138566699 title "Electron Microscopy of Ryanodine Receptors" @default.
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• W138566699 doi "https://doi.org/10.1016/s1063-5823(10)66002-4" @default.

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