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- W138591998 abstract "The rate of entry of a toxicant into a biological system is an important factor in the determination of toxicity, and penetration is often cited as a major factor contributing to selectivity. This chapter describes a preliminary study of penetration in a rabbit, which was designed to obtain a measure of the comparative rate of appearance of pesticides in blood within the early time intervals of application. In the method described in the chapter, the neck region of the body was shaved 24 hours prior to the application of pesticides. Pesticides were applied in 0.1 ml acetone containing 1 mgr of nonradioactive pesticide per kilogram body weight and about 20 μCi of labeled material. The solution of pesticide was allowed to spread over a 2 cm2 area of previously shaved skin. A blood sample of 1.0 ml was obtained by venapuncture from ear veins. Total urine and feces were collected separately over a 24-hour period. Animals were sacrificed and various organs were removed and assayed for radioactivity. After 1 minute, more carbaryl was found in the blood than all other compounds except parathion which was not significantly different from carbaryl. At the 5-minute interval, carbaryl appeared to penetrate faster than all compounds except parathion and aminotrizole." @default.
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- W138591998 date "1977-01-01" @default.
- W138591998 modified "2023-09-27" @default.
- W138591998 title "Dermal Absorption, Distribution, and the Fate of Six Pesticides in the Rabbit" @default.
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- W138591998 doi "https://doi.org/10.1016/b978-0-12-738650-8.50047-3" @default.
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