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• W13859770 abstract "Urea transporter gene knockout mice have been created for the study of the urine-concentrating mechanism. The major findings in studies of the renal phenotype of these mice are as follows: (1) Urea accumulation in the inner medullary interstitium is dependent on intrarenal urea recycling mediated by urea transporters; (2) urea transporters are essential for preventing urea-induced osmotic diuresis and thus for water conservation; (3) NaCl concentration in the inner medullary interstitium is not significantly affected by the absence of IMCD, descending limb of Henle and descending vasa recta urea transporters. Studies in urea transporter knockout mouse models have highlighted the essential role of urea for producing maximally concentrated urine." @default.
• W13859770 created "2016-06-24" @default.
• W13859770 creator A5047160585 @default.
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• W13859770 date "2014-01-01" @default.
• W13859770 modified "2023-09-24" @default.
• W13859770 title "Urea Transporter Knockout Mice and Their Renal Phenotypes" @default.
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• W13859770 doi "https://doi.org/10.1007/978-94-017-9343-8_9" @default.
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