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- W138611207 abstract "This chapter discusses the ultrastructure of glomerular lesions in KK mice. In an experiment described in the chapter, electron microscope examinations were made in 20 KK mice and 18 controls from a group of 320 KK and 180 control mice. All animals were maintained on an 11 % fat diet under standard laboratory conditions. Electron microscopy revealed an increase in mesangial cells and matrix which in the early phases and in young animals did not result in widening of the mesangial space. It was found that with increase in mesangium, the mesangial space may be markedly widened. Usually, the mesangial accumulation is accompanied by cells; however, in a few instances, there are small, dense accumulations of mesangial matrix without mesangial cells. As the mesangium proliferates, it grows into the capillary wall and tends to be get inserted between the basement membrane and the endothelium. In advanced cases, the capillary lumen may be partly occluded by the mass of mesangium. Collagen fibrils are found in the mesangial matrix in some instances. Electron-dense deposits are also seen in the mesangial matrix, beneath the capillary endothelium, in the basement membrane, and occasionally partly occluding the capillary lumen." @default.
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- W138611207 date "1973-01-01" @default.
- W138611207 modified "2023-10-18" @default.
- W138611207 title "Ultrastructure of Glomerular Lesions in KK Mice" @default.
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- W138611207 doi "https://doi.org/10.1016/b978-0-12-027362-1.50034-0" @default.
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