Matches in SemOpenAlex for { <https://semopenalex.org/work/W138616062> ?p ?o ?g. }
- W138616062 abstract "The eukaryotic cell nucleus performs a series of tasks including replication and packaging of DNA and transcription, splicing, polyadenylation, and transport of RNA. Productive infection of cells by viruses is the result of complex interactions between host and viral components that effectively subvert much of the host cell machinery for replication and gene expression of the virus. In a sense, the virus is able to reprogram the host cell, resulting in dramatic changes in host gene expression and allowing for the efficient production of viral particles. Biochemical and genetic analyses of adenovirus-infected cells have provided an enormous amount of information about the interaction of host and viral factors during the infectious program (see Doerfler 1986). Virus infection also alters structural and morphological characteristics of host nuclei (Martinez-Polomo and Granboulan 1967; Martinez-Polomo et al. 1967; Phillips and Raskas 1972; Vlak et al. 1975; Moyne et al. 1978). Adenovirus and herpesvirus replicate and accumulate DNA within distinct nuclear compartments, and host factors have also been shown to localize to these compartments (Walton et al. 1989; Wilcock and Lane 1991 ). Part of the viral reprogramming process is the formation of new virus-dependent nuclear structures and the alteration of existing nuclear structures. The role of the architecture and structural components of the nucleus in the replication and expression of both host and viral genomes is only beginning to be explored." @default.
- W138616062 created "2016-06-24" @default.
- W138616062 creator A5056057695 @default.
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- W138616062 date "1995-01-01" @default.
- W138616062 modified "2023-10-03" @default.
- W138616062 title "Nuclear Organization of Replication and Gene Expression in Adenovirus-Infected Cells" @default.
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- W138616062 doi "https://doi.org/10.1007/978-3-642-79496-4_7" @default.
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