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- W138722675 abstract "Dietary protein is critical to mammalian nutrition and on a cellular level this translates into amino acid availability. Cells monitor amino acids and respond with changes in cellular processes, including gene transcription. Thus, amino acids serve as signal molecules to transmit the nutritional status of the organism to individual cells. Using two target genes, CHOP and asparagine synthetase, this chapter will review the transcriptional control mechanisms triggered by amino acid limitation, a pathway named the amino acid response. The transcription factors, identified thus far, belong to two subfamilies, C/EBP and ATF, of the bZIP superfamily. There is much yet to learn about the signal pathways and the molecular mechanisms responsible for transcriptional regulation by nutrients. Beyond gaining a basic understanding of these biological control mechanisms, characterizing how these processes contribute to the pathology of various disease states represents an exciting aspect of molecular nutrition." @default.
- W138722675 created "2016-06-24" @default.
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- W138722675 date "2004-01-01" @default.
- W138722675 modified "2023-10-11" @default.
- W138722675 title "1 Transcriptional regulatory mechanisms for the response to amino acid deprivation of mammalian cells" @default.
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- W138722675 doi "https://doi.org/10.1007/978-3-540-39898-1_2" @default.
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