Matches in SemOpenAlex for { <https://semopenalex.org/work/W138799327> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W138799327 endingPage "2074" @default.
- W138799327 startingPage "2071" @default.
- W138799327 abstract "Background: Prostate cancer is the second leading cause of death among men in Western countries. Genetic alterations of the estrogen receptor gene are known to be indicative of a higher risk of this disease. The estrogen receptor gene is found as two subtypes, a and β. In this study the estrogen receptor a and fi genes were tested in 2 human prostate cancer cell lines: the hormone-sensitive PC-EW and the hormone-independent PC-OR. Materials and Methods: Genomic DNA was isolated from 2 cell lines from metastatic prostate adenocarcinoma in hetero-transplanted male athymic nude (nu/nu) Balb/c mice. Mutation screening was performed by sequencing of exons 1-8 and intron 1 of the human estrogen receptor gene a, and exons 1-9 of estrogen receptor gene β. Results: No point mutations were detected in the ER gene subtypes of either cell line. Polymorphisms were found of ER-a in exon 1, intron 1, exon 3, 4, 5, intron 6 and exon 8 and of ER-β in intron 2 and exon 9. Conclusion: Point mutations of ER-a and -βare not necessary for metastatic prostate cancer, alterations in different areas of the ER genes are more often found. These polymorphisms are a part of many genetic influences that accumulate to contribute to men's overall risk for developing prostate cancer." @default.
- W138799327 created "2016-06-24" @default.
- W138799327 creator A5014763341 @default.
- W138799327 creator A5020129270 @default.
- W138799327 creator A5020397561 @default.
- W138799327 creator A5050402159 @default.
- W138799327 creator A5063337793 @default.
- W138799327 creator A5076433794 @default.
- W138799327 creator A5085027181 @default.
- W138799327 date "2007-07-01" @default.
- W138799327 modified "2023-09-26" @default.
- W138799327 title "Polymorphisms of human estrogen receptor (ER) gene alpha and beta in prostate cancer PC-EW and PC-OR cell lines." @default.
- W138799327 cites W2017291040 @default.
- W138799327 cites W2018991261 @default.
- W138799327 cites W2043766006 @default.
- W138799327 cites W2105740297 @default.
- W138799327 cites W2119849253 @default.
- W138799327 cites W2132291061 @default.
- W138799327 cites W2157104106 @default.
- W138799327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17649823" @default.
- W138799327 hasPublicationYear "2007" @default.
- W138799327 type Work @default.
- W138799327 sameAs 138799327 @default.
- W138799327 citedByCount "0" @default.
- W138799327 crossrefType "journal-article" @default.
- W138799327 hasAuthorship W138799327A5014763341 @default.
- W138799327 hasAuthorship W138799327A5020129270 @default.
- W138799327 hasAuthorship W138799327A5020397561 @default.
- W138799327 hasAuthorship W138799327A5050402159 @default.
- W138799327 hasAuthorship W138799327A5063337793 @default.
- W138799327 hasAuthorship W138799327A5076433794 @default.
- W138799327 hasAuthorship W138799327A5085027181 @default.
- W138799327 hasConcept C104317684 @default.
- W138799327 hasConcept C121608353 @default.
- W138799327 hasConcept C126322002 @default.
- W138799327 hasConcept C172313692 @default.
- W138799327 hasConcept C176944494 @default.
- W138799327 hasConcept C2776235491 @default.
- W138799327 hasConcept C2780192828 @default.
- W138799327 hasConcept C36823959 @default.
- W138799327 hasConcept C501734568 @default.
- W138799327 hasConcept C502942594 @default.
- W138799327 hasConcept C530470458 @default.
- W138799327 hasConcept C54355233 @default.
- W138799327 hasConcept C71924100 @default.
- W138799327 hasConcept C84606932 @default.
- W138799327 hasConcept C86803240 @default.
- W138799327 hasConcept C94671646 @default.
- W138799327 hasConcept C96307122 @default.
- W138799327 hasConceptScore W138799327C104317684 @default.
- W138799327 hasConceptScore W138799327C121608353 @default.
- W138799327 hasConceptScore W138799327C126322002 @default.
- W138799327 hasConceptScore W138799327C172313692 @default.
- W138799327 hasConceptScore W138799327C176944494 @default.
- W138799327 hasConceptScore W138799327C2776235491 @default.
- W138799327 hasConceptScore W138799327C2780192828 @default.
- W138799327 hasConceptScore W138799327C36823959 @default.
- W138799327 hasConceptScore W138799327C501734568 @default.
- W138799327 hasConceptScore W138799327C502942594 @default.
- W138799327 hasConceptScore W138799327C530470458 @default.
- W138799327 hasConceptScore W138799327C54355233 @default.
- W138799327 hasConceptScore W138799327C71924100 @default.
- W138799327 hasConceptScore W138799327C84606932 @default.
- W138799327 hasConceptScore W138799327C86803240 @default.
- W138799327 hasConceptScore W138799327C94671646 @default.
- W138799327 hasConceptScore W138799327C96307122 @default.
- W138799327 hasLocation W1387993271 @default.
- W138799327 hasLocation W1387993272 @default.
- W138799327 hasOpenAccess W138799327 @default.
- W138799327 hasPrimaryLocation W1387993271 @default.
- W138799327 hasRelatedWork W1558499345 @default.
- W138799327 hasRelatedWork W1944313250 @default.
- W138799327 hasRelatedWork W1967175473 @default.
- W138799327 hasRelatedWork W1973756075 @default.
- W138799327 hasRelatedWork W1980445173 @default.
- W138799327 hasRelatedWork W1995728036 @default.
- W138799327 hasRelatedWork W2002778961 @default.
- W138799327 hasRelatedWork W2014439698 @default.
- W138799327 hasRelatedWork W2017373957 @default.
- W138799327 hasRelatedWork W2037354833 @default.
- W138799327 hasRelatedWork W2052272118 @default.
- W138799327 hasRelatedWork W2065174899 @default.
- W138799327 hasRelatedWork W2066796013 @default.
- W138799327 hasRelatedWork W2088383332 @default.
- W138799327 hasRelatedWork W2105624630 @default.
- W138799327 hasRelatedWork W2111834665 @default.
- W138799327 hasRelatedWork W2125824383 @default.
- W138799327 hasRelatedWork W2155399095 @default.
- W138799327 hasRelatedWork W2163997234 @default.
- W138799327 hasRelatedWork W1966686577 @default.
- W138799327 hasVolume "27" @default.
- W138799327 isParatext "false" @default.
- W138799327 isRetracted "false" @default.
- W138799327 magId "138799327" @default.
- W138799327 workType "article" @default.