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- W13882496 abstract "This article reviews the biophysical properties of membrane GABA transporters as they relate to the regulation of extracellular GABA concentrations. Special attention is paid to the dynamic changes in the membrane potential of neurons, and in concentrations of substrate for GABA transporters (GABA, Na + , and Cl − ), and the predicted effects these changes would have on GABA transporter function. In particular, we discuss experimental results supporting a role of GABA transporters in the determination of ambient [GABA] in the brain. We conclude that GABA transporters are well suited to maintain ambient [GABA] in the range necessary to maintain tonic inhibition mediated by high-affinity, extrasynaptic GABA A receptors. These extrasynaptic GABA A receptors play an important role in regulating cellular and network excitability." @default.
- W13882496 created "2016-06-24" @default.
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- W13882496 date "2009-01-01" @default.
- W13882496 modified "2023-09-25" @default.
- W13882496 title "TRANSPORTERS | GABA Transporters: Regulation of Tonic Inhibition" @default.
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- W13882496 doi "https://doi.org/10.1016/b978-012373961-2.00162-4" @default.
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