FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W138934520> ?p ?o ?g. }

• W138934520 endingPage "1467" @default.
• W138934520 startingPage "1455" @default.
• W138934520 abstract "In the study of carcinogenesis most interest has focused on carcinomas, as they represent the majority of human cancers. The recognition of the adenoma-carcinoma sequence both in humans and in animal experimental models has given the field of basic oncology the opportunity to elucidate individual mechanisms in the multistep development of carcinoma. The relative scarcity of human sarcomas coupled with the lack of adequate animal models has hampered understanding of the molecular genetic steps involved. We present an experimental model in the rat in which a high incidence of malignant mesenchymal tumors arise around a subcutaneously implanted biomaterial. Nine commercially available biomaterials were implanted in a total of 490 rats of the Fischer strain for 2 years. On average, macroscopic tumors were found in 25.8% of implantation sites over a period from 26 to 110 weeks after implantation. The most frequent tumors were malignant fibrous histiocytomas and pleomorphic sarcomas, although fibrosarcomas, leiomyosarcomas, and angiosarcomas readily developed, the latter especially around polyurethane implants. Of particular interest are the results of a detailed histological study of the capsules around the implanted biomaterials without tumors. Here a spectrum of change from focal proliferative lesions through preneoplastic proliferation to incipient sarcoma could be observed. A parallel immunohistochemical study of peri-implant capsules showed that proliferating cell nuclear antigen was of particular help in identifying these atypical proliferative lesions. To our knowledge this is the first description of a sarcoma model in which preneoplastic lesions can be readily identified and also reproducibly induced. This model provides the molecular biologist with defined stages in the development of mesenchymal malignancy, with which the multistage tumorigenesis hypothesis can be tested, analogous to the well-known adenoma-carcinoma sequence." @default.
• W138934520 created "2016-06-24" @default.
• W138934520 creator A5013778927 @default.
• W138934520 creator A5026461636 @default.
• W138934520 creator A5027443004 @default.
• W138934520 creator A5054931625 @default.
• W138934520 creator A5056763557 @default.
• W138934520 creator A5071651762 @default.
• W138934520 creator A5073467533 @default.
• W138934520 creator A5091319329 @default.
• W138934520 date "2000-04-01" @default.
• W138934520 modified "2023-10-14" @default.
• W138934520 title "Biomaterial-Induced Sarcoma" @default.
• W138934520 cites W1527974355 @default.
• W138934520 cites W1555580180 @default.
• W138934520 cites W1614977375 @default.
• W138934520 cites W1904580552 @default.
• W138934520 cites W1907311402 @default.
• W138934520 cites W1940183233 @default.
• W138934520 cites W1953869527 @default.
• W138934520 cites W1966106633 @default.
• W138934520 cites W1966565219 @default.
• W138934520 cites W1977941824 @default.
• W138934520 cites W1979677889 @default.
• W138934520 cites W2018348035 @default.
• W138934520 cites W2032302185 @default.
• W138934520 cites W2039722727 @default.
• W138934520 cites W2043624815 @default.
• W138934520 cites W2049321028 @default.
• W138934520 cites W2061208476 @default.
• W138934520 cites W2061581683 @default.
• W138934520 cites W2069373327 @default.
• W138934520 cites W2080508857 @default.
• W138934520 cites W2103421189 @default.
• W138934520 cites W2129930708 @default.
• W138934520 cites W2132739571 @default.
• W138934520 cites W2135025955 @default.
• W138934520 cites W2150692393 @default.
• W138934520 cites W2151501987 @default.
• W138934520 cites W2169962182 @default.
• W138934520 cites W2219736375 @default.
• W138934520 cites W2294308823 @default.
• W138934520 cites W2400759110 @default.
• W138934520 cites W2415502126 @default.
• W138934520 cites W2416067016 @default.
• W138934520 cites W2418958395 @default.
• W138934520 cites W4322701571 @default.
• W138934520 cites W85004574 @default.
• W138934520 cites W2009202996 @default.
• W138934520 doi "https://doi.org/10.1016/s0002-9440(10)65014-6" @default.
• W138934520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1876896" @default.
• W138934520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10751369" @default.
• W138934520 hasPublicationYear "2000" @default.
• W138934520 type Work @default.
• W138934520 sameAs 138934520 @default.
• W138934520 citedByCount "108" @default.
• W138934520 countsByYear W1389345202012 @default.
• W138934520 countsByYear W1389345202013 @default.
• W138934520 countsByYear W1389345202014 @default.
• W138934520 countsByYear W1389345202015 @default.
• W138934520 countsByYear W1389345202016 @default.
• W138934520 countsByYear W1389345202018 @default.
• W138934520 countsByYear W1389345202019 @default.
• W138934520 countsByYear W1389345202020 @default.
• W138934520 countsByYear W1389345202021 @default.
• W138934520 countsByYear W1389345202022 @default.
• W138934520 countsByYear W1389345202023 @default.
• W138934520 crossrefType "journal-article" @default.
• W138934520 hasAuthorship W138934520A5013778927 @default.
• W138934520 hasAuthorship W138934520A5026461636 @default.
• W138934520 hasAuthorship W138934520A5027443004 @default.
• W138934520 hasAuthorship W138934520A5054931625 @default.
• W138934520 hasAuthorship W138934520A5056763557 @default.
• W138934520 hasAuthorship W138934520A5071651762 @default.
• W138934520 hasAuthorship W138934520A5073467533 @default.
• W138934520 hasAuthorship W138934520A5091319329 @default.
• W138934520 hasBestOaLocation W1389345201 @default.
• W138934520 hasConcept C10205521 @default.
• W138934520 hasConcept C121608353 @default.
• W138934520 hasConcept C126322002 @default.
• W138934520 hasConcept C142724271 @default.
• W138934520 hasConcept C198826908 @default.
• W138934520 hasConcept C2776495794 @default.
• W138934520 hasConcept C2777532014 @default.
• W138934520 hasConcept C2777546739 @default.
• W138934520 hasConcept C2778117688 @default.
• W138934520 hasConcept C2778256501 @default.
• W138934520 hasConcept C2780071746 @default.
• W138934520 hasConcept C28328180 @default.
• W138934520 hasConcept C54355233 @default.
• W138934520 hasConcept C555283112 @default.
• W138934520 hasConcept C71924100 @default.
• W138934520 hasConcept C86803240 @default.
• W138934520 hasConceptScore W138934520C10205521 @default.
• W138934520 hasConceptScore W138934520C121608353 @default.
• W138934520 hasConceptScore W138934520C126322002 @default.
• W138934520 hasConceptScore W138934520C142724271 @default.
• W138934520 hasConceptScore W138934520C198826908 @default.

• next