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- W139137007 abstract "This chapter discusses dose-intensive chemotherapy in patients with germ cell tumors (GCT). Approximately 70–80% of patients with disseminated GCT achieve a complete response (CR) to cisplatin-based chemotherapy. Cyclophosphamide was selected for use in combination with carboplatin and etoposide based on its demonstrated antitumor activity against GCT as a single agent, the in-vitro synergism of cyclophosphamide with etoposide and cisplatin, a relative lack of nonhematological toxicity, and prior experience in combination with etoposide in dose-intensive therapy for GCT patients. The most frequent nonhematological toxicity was hepatic, and there were two (7%) treatment-related deaths. Evidence that the addition of an oxazophosphorine (cyclophosphamide, ifosfamide) to carboplatin and etoposide adds efficacy has been suggested by two recent reviews. As the major toxicities of high-dose chemotherapy are cumulative, early intervention in patients predicted to be cisplatin-resistant warrants investigation. Patients with mediastinal GCT and those with absolute refractory GCT should be considered for novel investigational treatment programmes. Phase II trials to identify new active agents remain a priority and may be more successful if entry restrictions requiring extensive pretreatment be eliminated." @default.
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- W139137007 date "1994-01-01" @default.
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- W139137007 title "Dose-Intensive Chemotherapy in Patients with Germ Cell Tumours: The Memorial Sloan-Kettering Cancer Center Experience" @default.
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- W139137007 doi "https://doi.org/10.1016/b978-0-08-042198-8.50070-4" @default.
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