Matches in SemOpenAlex for { <https://semopenalex.org/work/W139182013> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W139182013 abstract "Three-dimensional conformation of proteins can be solved with greater ease by utilizing unnatural amino acids (UAA), along with x-ray crystallography. Because atoms naturally occurring in proteins do not have sufficient mass to interact with x-ray radiation UAA, telluromethionine (TeMet), offers a solution to the “phasing problem”. Hijacking the molecular machinery of cells makes incorporation of TeMet easy, unfortunately, cytotoxicity of TeMet substantially reduces in vivo uptake. Differential expression of a methionine auxotroph, Eschericia coli DL41, can show differences between cells forced to use TeMet in the translation of proteins and cells grown in an authentic methionine environment. Protein profiling of these systems can reveal a molecular snapshot of E. coli DL41 at any given time. The condition of the cell, whether sick or healthy, young or old, can be viewed, quite literally, through proteomics. Detection with UPLC/qTOF MS enables the identification of changes in normal verses diseased states, allowing for the identification of proteins responsible for cell death. Toxic effects due to TeMet can then be reduced, thereby, providing a new tool for the elucidation of 3D structure." @default.
- W139182013 created "2016-06-24" @default.
- W139182013 creator A5002766082 @default.
- W139182013 creator A5037026723 @default.
- W139182013 date "2010-04-01" @default.
- W139182013 modified "2023-10-14" @default.
- W139182013 title "Proteomic profiling of unnatural amino acid toxicity through differential expression of wild type vs. telluroproteins in Eschericia coli DL41(DE3)" @default.
- W139182013 doi "https://doi.org/10.1096/fasebj.24.1_supplement.522.2" @default.
- W139182013 hasPublicationYear "2010" @default.
- W139182013 type Work @default.
- W139182013 sameAs 139182013 @default.
- W139182013 citedByCount "0" @default.
- W139182013 crossrefType "journal-article" @default.
- W139182013 hasAuthorship W139182013A5002766082 @default.
- W139182013 hasAuthorship W139182013A5037026723 @default.
- W139182013 hasConcept C104317684 @default.
- W139182013 hasConcept C109316439 @default.
- W139182013 hasConcept C162356407 @default.
- W139182013 hasConcept C185592680 @default.
- W139182013 hasConcept C202751555 @default.
- W139182013 hasConcept C20950039 @default.
- W139182013 hasConcept C2780912031 @default.
- W139182013 hasConcept C43617362 @default.
- W139182013 hasConcept C46111723 @default.
- W139182013 hasConcept C515207424 @default.
- W139182013 hasConcept C547475151 @default.
- W139182013 hasConcept C55493867 @default.
- W139182013 hasConcept C70721500 @default.
- W139182013 hasConcept C86803240 @default.
- W139182013 hasConceptScore W139182013C104317684 @default.
- W139182013 hasConceptScore W139182013C109316439 @default.
- W139182013 hasConceptScore W139182013C162356407 @default.
- W139182013 hasConceptScore W139182013C185592680 @default.
- W139182013 hasConceptScore W139182013C202751555 @default.
- W139182013 hasConceptScore W139182013C20950039 @default.
- W139182013 hasConceptScore W139182013C2780912031 @default.
- W139182013 hasConceptScore W139182013C43617362 @default.
- W139182013 hasConceptScore W139182013C46111723 @default.
- W139182013 hasConceptScore W139182013C515207424 @default.
- W139182013 hasConceptScore W139182013C547475151 @default.
- W139182013 hasConceptScore W139182013C55493867 @default.
- W139182013 hasConceptScore W139182013C70721500 @default.
- W139182013 hasConceptScore W139182013C86803240 @default.
- W139182013 hasIssue "S1" @default.
- W139182013 hasLocation W1391820131 @default.
- W139182013 hasOpenAccess W139182013 @default.
- W139182013 hasPrimaryLocation W1391820131 @default.
- W139182013 hasRelatedWork W111279495 @default.
- W139182013 hasRelatedWork W1576754341 @default.
- W139182013 hasRelatedWork W1579221818 @default.
- W139182013 hasRelatedWork W1602349845 @default.
- W139182013 hasRelatedWork W1645722049 @default.
- W139182013 hasRelatedWork W2098225763 @default.
- W139182013 hasRelatedWork W2118979234 @default.
- W139182013 hasRelatedWork W2149849649 @default.
- W139182013 hasRelatedWork W2223310357 @default.
- W139182013 hasRelatedWork W4211021704 @default.
- W139182013 hasVolume "24" @default.
- W139182013 isParatext "false" @default.
- W139182013 isRetracted "false" @default.
- W139182013 magId "139182013" @default.
- W139182013 workType "article" @default.