Matches in SemOpenAlex for { <https://semopenalex.org/work/W139336039> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W139336039 abstract "Selenium-containing compounds have demonstrated chemopreventive activity in a variety of chemically-induced tumor models, but a unifying mechanism for this effect remains elusive. Altered disposition of chemicals and toxic metabolites may be contributing factors. Following dietary ingestion of selenocysteine pro-drugs and selenocystine (15 ppm Se) for 1 month, mouse hepatic glutathione transferase, quinone oxidoreductase and microsomal epoxide hydrolase activities were elevated by 2-butyl- and 2-oxoselenazolidine-4-carboxylic acids (SCAs) and selenocystine, but not by 2-cyclohexyl-, 2-phenyl-, and 2-(2′-hydroxyphenyl)- SCAs. Expression of multidrug resistance-associated proteins and other Abc transporters were evaluated by qPCR. Of 10 transporters examined, none responded in a pattern similar to the activities of the enzymes capable of being regulated via the Nrf2/ARE mechanism. Abcc3 (Mrp3) was increased only by 2-butylSCA and no transporters were induced by 2-oxoSCA or selenocystine. 2-(2′-Hydroxyphenyl)SCA was the only compound that induced expression of Abcc2 (Mrp2) and Abcb6. All the selenocompounds reduced the expression of Abcb11. Expression of Abcc1, Abcc4, Abcc5, Abcc6, and Abcg2 and Abca3, was not altered by any compound. Selenocompound regulation of Abc transporter expression appears to be compound dependent and unrelated to the Nrf2/ARE pathway. Support: GM 058913" @default.
- W139336039 created "2016-06-24" @default.
- W139336039 creator A5006945103 @default.
- W139336039 creator A5011533945 @default.
- W139336039 creator A5054148025 @default.
- W139336039 creator A5055250563 @default.
- W139336039 creator A5087471153 @default.
- W139336039 date "2008-03-01" @default.
- W139336039 modified "2023-09-26" @default.
- W139336039 title "Regulation of ATP‐binding cassette (Abc) transporters by organoselenium compounds" @default.
- W139336039 doi "https://doi.org/10.1096/fasebj.22.1_supplement.921.18" @default.
- W139336039 hasPublicationYear "2008" @default.
- W139336039 type Work @default.
- W139336039 sameAs 139336039 @default.
- W139336039 citedByCount "0" @default.
- W139336039 crossrefType "journal-article" @default.
- W139336039 hasAuthorship W139336039A5006945103 @default.
- W139336039 hasAuthorship W139336039A5011533945 @default.
- W139336039 hasAuthorship W139336039A5054148025 @default.
- W139336039 hasAuthorship W139336039A5055250563 @default.
- W139336039 hasAuthorship W139336039A5087471153 @default.
- W139336039 hasConcept C104317684 @default.
- W139336039 hasConcept C149011108 @default.
- W139336039 hasConcept C185592680 @default.
- W139336039 hasConcept C44312359 @default.
- W139336039 hasConcept C55493867 @default.
- W139336039 hasConcept C70721500 @default.
- W139336039 hasConcept C86803240 @default.
- W139336039 hasConceptScore W139336039C104317684 @default.
- W139336039 hasConceptScore W139336039C149011108 @default.
- W139336039 hasConceptScore W139336039C185592680 @default.
- W139336039 hasConceptScore W139336039C44312359 @default.
- W139336039 hasConceptScore W139336039C55493867 @default.
- W139336039 hasConceptScore W139336039C70721500 @default.
- W139336039 hasConceptScore W139336039C86803240 @default.
- W139336039 hasIssue "S1" @default.
- W139336039 hasLocation W1393360391 @default.
- W139336039 hasOpenAccess W139336039 @default.
- W139336039 hasPrimaryLocation W1393360391 @default.
- W139336039 hasRelatedWork W2038766809 @default.
- W139336039 hasRelatedWork W2049054518 @default.
- W139336039 hasRelatedWork W2052869590 @default.
- W139336039 hasRelatedWork W2060781056 @default.
- W139336039 hasRelatedWork W2072596831 @default.
- W139336039 hasRelatedWork W2085955934 @default.
- W139336039 hasRelatedWork W2088575858 @default.
- W139336039 hasRelatedWork W2129083787 @default.
- W139336039 hasRelatedWork W2340363796 @default.
- W139336039 hasRelatedWork W4285216951 @default.
- W139336039 hasVolume "22" @default.
- W139336039 isParatext "false" @default.
- W139336039 isRetracted "false" @default.
- W139336039 magId "139336039" @default.
- W139336039 workType "article" @default.