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- W139497788 abstract "Since 1940 chemotherapy has been one of the major therapies used to kill cancer cells. However, conventional standard cytotoxic agents have a low therapeutic index and often show toxicity in healthy cells. Over the past decade, progress in molecular biology and genomics has identified signaling pathways and mutations driving different types of cancer. Genetic and epigenetic alterations that characterize tumor cells have been used in the development of targeted therapy, a very active area of cancer research. Moreover, identification of synthetic lethal interactions between two altered genes in cancer cells shows much promise to target specifically tumor cells. For a long time, apoptosis was considered the principal mechanism by which cells die from chemotherapeutic agents. Autophagy, necroptosis (a programmed cell death mechanism of necrosis), and lysosomal-mediated cell death significantly improve our understanding of how malignancy can be targeted by anticancer treatments. Autophagy is a highly regulated process by which misfolded proteins and organelles reach lysosomes for their degradation. Alterations in this cellular process have been observed in several pathological conditions, including cancer. The role of autophagy in cancer raised a paradox wherein it can act as a tumor suppressor at early stage of tumor development but can also be used by cancer cells as cytoprotection to promote survival in established tumors. It is interesting that autophagy can be targeted by anticancer agents to provoke cancer cell death. This review focuses on the role of autophagy in cancer cells and its potential to therapeutically kill cancer cells." @default.
- W139497788 created "2016-06-24" @default.
- W139497788 creator A5037297516 @default.
- W139497788 creator A5043211437 @default.
- W139497788 creator A5063603722 @default.
- W139497788 date "2013-10-23" @default.
- W139497788 modified "2023-10-06" @default.
- W139497788 title "Autophagy and Cell Death to Target Cancer Cells: Exploiting Synthetic Lethality as Cancer Therapies" @default.
- W139497788 cites W1712093210 @default.
- W139497788 cites W1784425676 @default.
- W139497788 cites W1964032090 @default.
- W139497788 cites W1964052965 @default.
- W139497788 cites W1964612156 @default.
- W139497788 cites W1964661396 @default.
- W139497788 cites W1966828940 @default.
- W139497788 cites W1968444524 @default.
- W139497788 cites W1970887825 @default.
- W139497788 cites W1972215727 @default.
- W139497788 cites W1972336737 @default.
- W139497788 cites W1973268287 @default.
- W139497788 cites W1975200363 @default.
- W139497788 cites W1975931018 @default.
- W139497788 cites W1977431691 @default.
- W139497788 cites W1977767269 @default.
- W139497788 cites W1977841275 @default.
- W139497788 cites W1979318345 @default.
- W139497788 cites W1990960113 @default.
- W139497788 cites W1991421091 @default.
- W139497788 cites W1991692801 @default.
- W139497788 cites W1996362044 @default.
- W139497788 cites W1996926758 @default.
- W139497788 cites W1999966467 @default.
- W139497788 cites W2001284886 @default.
- W139497788 cites W2001761748 @default.
- W139497788 cites W2002061608 @default.
- W139497788 cites W2002724336 @default.
- W139497788 cites W2003047743 @default.
- W139497788 cites W2008417639 @default.
- W139497788 cites W2009007206 @default.
- W139497788 cites W2009931781 @default.
- W139497788 cites W2011159055 @default.
- W139497788 cites W2013113192 @default.
- W139497788 cites W2014918593 @default.
- W139497788 cites W2017289276 @default.
- W139497788 cites W2017779665 @default.
- W139497788 cites W2020241889 @default.
- W139497788 cites W2027785297 @default.
- W139497788 cites W2027951311 @default.
- W139497788 cites W2032186831 @default.
- W139497788 cites W2034043992 @default.
- W139497788 cites W2034132952 @default.
- W139497788 cites W2034339677 @default.
- W139497788 cites W2035799305 @default.
- W139497788 cites W2038781838 @default.
- W139497788 cites W2038870226 @default.
- W139497788 cites W2040149266 @default.
- W139497788 cites W2042377836 @default.
- W139497788 cites W2048571348 @default.
- W139497788 cites W2049544802 @default.
- W139497788 cites W2051811673 @default.
- W139497788 cites W2052065041 @default.
- W139497788 cites W2055150942 @default.
- W139497788 cites W2057274775 @default.
- W139497788 cites W2057317080 @default.
- W139497788 cites W2065592028 @default.
- W139497788 cites W2066800765 @default.
- W139497788 cites W2068862752 @default.
- W139497788 cites W2071478061 @default.
- W139497788 cites W2074272918 @default.
- W139497788 cites W2074305443 @default.
- W139497788 cites W2077499130 @default.
- W139497788 cites W2078527512 @default.
- W139497788 cites W2084946596 @default.
- W139497788 cites W2085442981 @default.
- W139497788 cites W2086853865 @default.
- W139497788 cites W2087046564 @default.
- W139497788 cites W2089074573 @default.
- W139497788 cites W2090356352 @default.
- W139497788 cites W2091821324 @default.
- W139497788 cites W2095445076 @default.
- W139497788 cites W2096348285 @default.
- W139497788 cites W2097845436 @default.
- W139497788 cites W2100669312 @default.
- W139497788 cites W2101158381 @default.
- W139497788 cites W2101228747 @default.
- W139497788 cites W2105114667 @default.
- W139497788 cites W2105677187 @default.
- W139497788 cites W2106972520 @default.
- W139497788 cites W2107975811 @default.
- W139497788 cites W2108086395 @default.
- W139497788 cites W2109034822 @default.
- W139497788 cites W2109840033 @default.
- W139497788 cites W2111607026 @default.
- W139497788 cites W2113432343 @default.
- W139497788 cites W2114847797 @default.
- W139497788 cites W2115886998 @default.
- W139497788 cites W2116836791 @default.
- W139497788 cites W2117874431 @default.