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- W139873648 abstract "1414 Objectives The myocardial wall thickness is comparable to the spatial resolution of most clinical whole-body PET systems. The quantitative accuracy of both myocardial and blood pool activity concentrations, respectively, are affected from partial volume and spillover effects. Our goal is to investigate if a cardiac-dedicated high-resolution PET system is able to improve the quantitative accuracy of myocardial blood flow compared to the standard clinical systems. Methods A simplified heart phantom image was generated and was convolved with Gaussian kernels which have FWHM values ranging from 1 to 12 mm. A set of activity concentration ratios between the myocardium (Cm) and blood pool (Cb) compartments were studied, for both the accumulation and washout periods. The ratio between the myocardium activity concentrations after (Cafter) and before (Cbefore) the resolution blurring was characterized. Gaussian random noise was added to the raw data and 10 trials were performed to estimate the variations of parameters. An un-weighted nonlinear, least square algorithm was implemented to derive the K1, k2 and k3. Results The quantitation of Cm depends on both spatial resolution and activity concentration ratio. In the uptake period, the limited spatial resolution results in ~30%underestimation of the myocardial activity. While in the washout period, the limited spatial resolution results in ~20% overestimation of the myocardium activity with the exception for the low activity concentration ratios 2:1 and 1:1. The linear dependence of K1 on spatial resolution is observed. The estimated K1 (ml/g/min) is 0.96 , 0.53, and 0.38 at spatial resolution FWHM of 1 mm, 8 mm, and 12 mm, respectively. No strong dependency is found for k2 and k3 on spatial resolution. Conclusions The results indicate that a cardiac-dedicated high resolution PET system has the potential to significantly reduce the bias in myocardium blood flow quantification. Such quantitation improvements translate into more accurate estimation of coronary flow reserve and more reliable prediction of cardiac death" @default.
- W139873648 created "2016-06-24" @default.
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- W139873648 date "2010-05-01" @default.
- W139873648 modified "2023-09-23" @default.
- W139873648 title "Would a high resolution cardiac-dedicated PET system improve quantification of myocardial blood flow?" @default.
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