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- W139916947 abstract "As obesity becomes an increasing health problem, there have been an increasing number of endogenous peptides discovered that affect the ingestion of food. Ingestive peptides may exert their actions in the brain, whereas peripheral sources provide a ready reserve. The availability of ingestive peptides to central nervous system targets can be regulated by the blood–brain barrier (BBB). Some of the peptides/polypeptides are transported by saturable mechanisms from blood to brain (e.g., leptin, insulin, mahogany, pancreatic polypeptide) and some enter the brain by passive diffusion (e.g., neuropeptide Y, orexin A, CART, cycloHis–Pro, amylin). Some others may have essentially no penetration of the BBB (e.g., agouti–related protein, melanin–concentrating hormone, urocortin). The regulatory function of the BBB can be seen in various physiological states. Hyperglycemia may upregulate transport systems for leptin, urocortin, and galanin–like peptide, whereas fasting can downregulate those for leptin and galanin–like peptide. Thus, the BBB plays a dynamic role in modulating the passage of ingestive peptides from blood to brain." @default.
- W139916947 created "2016-06-24" @default.
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- W139916947 date "2004-01-01" @default.
- W139916947 modified "2023-10-16" @default.
- W139916947 title "Brain Influx of Endogenous Peptides Affecting Food Intake" @default.
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- W139916947 doi "https://doi.org/10.1016/b978-012639011-7/50010-3" @default.
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