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- W139969668 abstract "Vizsgalataink soran megallapitottuk, hogy az altatoszerek modositjak a gyogyszerek proaritmias hatasat nyulakban. Mivel a vagotomia vedő hatasu volt, a vegetativ idegrendszer valoszinűleg befolyasolja a gyogyszerek proaritmias hatasait nyulban, de ennek reszletei tovabbi tisztazasra varnak. Az EKG-n merhető repolarizacios parameterek nem jelzik előre a dofetilid okozta torsades de pointes kialakulasat nyulban. Allando kamrafeszules, tartos magasvernyomas es intracardialis alfa1 adrenoceptor izgalom nem fokozza a dofetilid proaritmias hatasat nyulban. A Na+/Ca2+ exchanger (NCX) szelektiv gatlasa nem csokkenti a dofetilid proaritmias hatasat izolalt nyul szivben. Az NCX gatlas patkanyban pozitiv inotrop hatasu, mig nyulban nem befolyasolja a kontraktilitast. E fajspecifikus kulonbseg hattereben nem az NCX gatlo (SEA0400) elterő farmakodinamiai hatasa vagy az NCX elterő expresszioja all. | Our results show that intravenous anaesthetics may modify the proarrhythmic effects of drugs in rabbits. Since vagotomy prevented torsades de pointes, autonomic nervous system (ANS) may affect the proarrhithmic reactions in rabbits, however, further examinations are needed to clarify the effect of ANS on proarrhythmia. The repolarization related parameters of the ECG did not predict dofetilide-induced torsades de pointes in rabbits. Standard ventricular stretch, high blood pressure and intracardiac alpha1-adrenoceptor stimulation did not promote the proarrhythmic activity of dofetilide. The selective inhibition of the Na+/Ca2+ exchanger (NCX) with SEA0400 did not reduce the incidence of dofetilide-induced torsades de pointes in isolated perfused rabbit hearts. The inhibition of the NCX elevated inotropy in isolated rat hearts, but failed to affect contractility in isolated rabbit hearts. This interspecies difference was not related to the pharmacodynamic properties of the SEA0400 or the NCX expression." @default.
- W139969668 created "2016-06-24" @default.
- W139969668 creator A5042693942 @default.
- W139969668 date "2008-01-01" @default.
- W139969668 modified "2023-09-22" @default.
- W139969668 title "Az antiaritmiás gyógyszerek proaritmiás hatását befolyásoló tényezők vizsgálata = Examination of the factors that influence the proarrhythmic effects of the antiarrhythmic drugs" @default.
- W139969668 hasPublicationYear "2008" @default.
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