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- W140177980 abstract "High resolution and colour vision is derived from cone photoreceptors within the retina of theeye. These highly specialised neuronal cells convert energy from incident light into changesin cellular membrane potential. Action potentials are then relayed and processed within theinner retina and the cerebral cortex. Loss of function in the cone photoreceptors is the directcause of visual loss for millions o f patients. Yet for many of the most common causes ofblindness cone photoreceptor dysfunction occurs late on in the disease and is secondary toinherited and/or environmental influences that primarily affect other cell types. Conephotoreceptors are then secondarily affected and it is once their function is lost that the patientbecomes visually disabled.The aim of this thesis was to evaluate therapies targeting the molecular steps of conephotoreceptor death rather than the underlying pathology. If effective at slowing conephotoreceptor degeneration and preserving function, such therapies could be applicable tolarge numbers of patients with a variety of underlying defects. There will however becontinued stimuli for cell death as the primary defect has not been corrected and so it isimportant to determine the magnitude and duration of any treatment effect. The experimentsof this thesis were performed in an animal model of inherited retinal degeneration derived toallow repeated in vivo assessments of cone photoreceptor function and survival. Genetherapy and intra-ocular injections were used to evaluate proteins with contrasting modes ofaction." @default.
- W140177980 created "2016-06-24" @default.
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- W140177980 date "2012-03-28" @default.
- W140177980 modified "2023-09-28" @default.
- W140177980 title "Cone photoreceptor neuroprotection in inherited retinal degenerations" @default.
- W140177980 hasPublicationYear "2012" @default.
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