FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W14019768> ?p ?o ?g. }

• W14019768 endingPage "194" @default.
• W14019768 startingPage "177" @default.
• W14019768 abstract "The growing threat of international terrorism brings with it new scenarios for disaster. For example, in the case of toxic organophosphorus compounds (OPs), it possible for terrorists to use known agents or inadvertently to produce highly toxic OPs of unknown structure as the result of attacks on chemical plants or stockpiles of pesticides and other chemicals. Defending against such agents requires rapid, sensitive, and specific detection of them and their biological effects. Thus, the development of biomarkers of human exposures to OPs is a vital component of the system of prediction and early diagnosis of induced diseases. The phosphylating properties of OPs lead to their differential interactions with various serine esterases. These enzymes include primary targets, e.g., acetylcholinesterase (AChE, acute toxicity) and neuropathy target esterase (NTE, delayed neuropathy, OPIDN); as well as secondary targets, e.g., butyrylcholinesterase (BChE) and carboxylesterase (CaE), which act as scavengers of OPs. The set of activities of these esterases as well as that of paraoxonase (PON1), which can hydrolyze and detoxify OPs, constitutes the “esterase status” of an organism that largely determines indi-vidual sensitivity to OPs and that may be used as a complex biomarker of exposure. This complex biomarker is more effective and informative than the standard determination of erythrocyte AChE and total blood cholinesterases. In particular, it assists with distinguishing between acute and delayed neurotoxicity induced by OPs, as we showed in experiments on acute exposure of hens to a neuropathic compound, O,O-dipropyl-O-dichlorovinyl phosphate. In addition, measuring decreased activities of BChE and CaE, which are often more sensitive biomarkers of OP exposure, allows us to reveal exposure to low doses, as demonstrated by treating mice with low doses of phosphorylated oximes. The aim of the ISTC Project summarized here is to develop a smart biosensor system for simultaneous analysis of a set of blood esterases including AChE, BChE, NTE, CaE, and PON1. The speed, sensitivity, and integrated approach of the method will allow hazards to be assessed and appropriate interventions to be recommended before overt toxic damage has occurred." @default.
• W14019768 created "2016-06-24" @default.
• W14019768 creator A5002693383 @default.
• W14019768 creator A5015968517 @default.
• W14019768 creator A5024189557 @default.
• W14019768 creator A5024769295 @default.
• W14019768 creator A5027730664 @default.
• W14019768 creator A5043190021 @default.
• W14019768 creator A5065825812 @default.
• W14019768 date "2009-01-01" @default.
• W14019768 modified "2023-09-27" @default.
• W14019768 title "Blood Esterases as a Complex Biomarker for Exposure to Organophosphorus Compounds" @default.
• W14019768 cites W1533545977 @default.
• W14019768 cites W157771309 @default.
• W14019768 cites W1964458064 @default.
• W14019768 cites W1964833626 @default.
• W14019768 cites W1967351568 @default.
• W14019768 cites W1967507582 @default.
• W14019768 cites W1971048984 @default.
• W14019768 cites W1976418350 @default.
• W14019768 cites W1977915898 @default.
• W14019768 cites W1979608974 @default.
• W14019768 cites W1980492851 @default.
• W14019768 cites W1984472389 @default.
• W14019768 cites W1996111288 @default.
• W14019768 cites W1997816136 @default.
• W14019768 cites W2002506700 @default.
• W14019768 cites W2007263077 @default.
• W14019768 cites W2008187599 @default.
• W14019768 cites W2008989087 @default.
• W14019768 cites W2017181323 @default.
• W14019768 cites W2017749725 @default.
• W14019768 cites W2017769985 @default.
• W14019768 cites W2023502993 @default.
• W14019768 cites W2027770484 @default.
• W14019768 cites W2031949107 @default.
• W14019768 cites W2037542007 @default.
• W14019768 cites W2044659011 @default.
• W14019768 cites W2054847996 @default.
• W14019768 cites W2057812939 @default.
• W14019768 cites W2065574821 @default.
• W14019768 cites W2072031910 @default.
• W14019768 cites W2075163322 @default.
• W14019768 cites W2077160008 @default.
• W14019768 cites W2078503590 @default.
• W14019768 cites W2085566853 @default.
• W14019768 cites W2086895101 @default.
• W14019768 cites W2091604814 @default.
• W14019768 cites W2095703183 @default.
• W14019768 cites W2099953575 @default.
• W14019768 cites W2101054185 @default.
• W14019768 cites W2110383233 @default.
• W14019768 cites W2116098232 @default.
• W14019768 cites W2123094796 @default.
• W14019768 cites W2126826655 @default.
• W14019768 cites W2128171635 @default.
• W14019768 cites W2143962579 @default.
• W14019768 cites W2163989217 @default.
• W14019768 cites W2166568504 @default.
• W14019768 cites W2216791376 @default.
• W14019768 cites W2494596789 @default.
• W14019768 cites W2506175729 @default.
• W14019768 cites W3023026416 @default.
• W14019768 cites W4235051170 @default.
• W14019768 cites W4240142220 @default.
• W14019768 cites W4243565052 @default.
• W14019768 doi "https://doi.org/10.1007/978-90-481-2342-1_22" @default.
• W14019768 hasPublicationYear "2009" @default.
• W14019768 type Work @default.
• W14019768 sameAs 14019768 @default.
• W14019768 citedByCount "7" @default.
• W14019768 countsByYear W140197682012 @default.
• W14019768 countsByYear W140197682014 @default.
• W14019768 countsByYear W140197682017 @default.
• W14019768 countsByYear W140197682021 @default.
• W14019768 countsByYear W140197682023 @default.
• W14019768 crossrefType "book-chapter" @default.
• W14019768 hasAuthorship W14019768A5002693383 @default.
• W14019768 hasAuthorship W14019768A5015968517 @default.
• W14019768 hasAuthorship W14019768A5024189557 @default.
• W14019768 hasAuthorship W14019768A5024769295 @default.
• W14019768 hasAuthorship W14019768A5027730664 @default.
• W14019768 hasAuthorship W14019768A5043190021 @default.
• W14019768 hasAuthorship W14019768A5065825812 @default.
• W14019768 hasConcept C104317684 @default.
• W14019768 hasConcept C135763542 @default.
• W14019768 hasConcept C161176658 @default.
• W14019768 hasConcept C181199279 @default.
• W14019768 hasConcept C185592680 @default.
• W14019768 hasConcept C2776414213 @default.
• W14019768 hasConcept C2776509667 @default.
• W14019768 hasConcept C2776588719 @default.
• W14019768 hasConcept C2777261171 @default.
• W14019768 hasConcept C2778325069 @default.
• W14019768 hasConcept C2778706303 @default.
• W14019768 hasConcept C2778816929 @default.
• W14019768 hasConcept C2779059548 @default.
• W14019768 hasConcept C2779101902 @default.

• next