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- W140464478 abstract "A substantial proportion of patients (40% to 50%) with supposedly localized esophageal cancer who had undergone curative surgical treatment with complete tumour removal suffer from a metastatic tumour relapse within 24 months after surgery. A reason for such an early tumour relapse in these patients might be a minimal tumour cell dissemination (minimal residual disease, MRD) present at the time of operation, which cannot be detected by clinical and routine histopathological tumour staging procedures. Over the past 10 years, more sensitive immunohisto-/-cytochemical and nucleic acid based assays have been developed that are based on the detection of epithelial cell-or tumour-associated marker proteins and are able to detect single tumour cells or small tumour cell clusters present in lymph nodes classified as tumour-free by conventional histopathologic analysis, bone marrow or blood. Here we present an overview of recent studies concerning the prevalence and prognostic value of occult tumour cells in lymph nodes and bone marrow of patients with esophageal cancer identified by antibody or nucleic acid based assays." @default.
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- W140464478 date "2005-12-30" @default.
- W140464478 modified "2023-09-26" @default.
- W140464478 title "Prognostic Value of Minimal Residual Disease in Esophageal Cancer" @default.
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