FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W140479576> ?p ?o ?g. }

• W140479576 endingPage "656" @default.
• W140479576 startingPage "648" @default.
• W140479576 abstract "We used DAMI human megakaryocytic leukemia cells to study transmembrane ion currents activated through the G-protein-coupled thrombin receptor pathway. When the cells were stimulated by thrombin receptor-activating peptide, an increase in cytosolic Ca2+ ([Ca2+]i) developed as predicted by the known effect that thrombin exerts in the platelet. We then monitored the membrane potentials of individual DAMI cells during this response and observed complex, triphasic changes that could not be accounted for by Ca2+ fluxes alone. These consisted of rapid hyperpolarization, followed by depolarization to values more positive than the resting potential and then by slow repolarization. For the purpose of this study, we focused on the hyperpolarizing current that developed immediately after thrombin receptor activation. This proved to be composed of (1) a Ca(2+)-independent, outwardly rectifying Cl- current and (2) a strongly hyperpolarizing, inwardly rectifying, Ba(2+)- sensitive K+ current that required an increase of [Ca2+]i for activation. By analogy with their functions in other cell systems, it is logical to conclude that these prominent K+ and Cl- conductances may serve to regulate the complex volume changes that accompany thrombin receptor activation and/or to increase the electromotive drive that supports Ca2+ influx under these conditions through hyperpolarization of the cell membrane." @default.
• W140479576 created "2016-06-24" @default.
• W140479576 creator A5004473951 @default.
• W140479576 creator A5015003674 @default.
• W140479576 creator A5071812338 @default.
• W140479576 date "1996-01-15" @default.
• W140479576 modified "2023-10-07" @default.
• W140479576 title "Thrombin receptors activate potassium and chloride channels" @default.
• W140479576 cites W1482508730 @default.
• W140479576 cites W1503660095 @default.
• W140479576 cites W1537934758 @default.
• W140479576 cites W1547563617 @default.
• W140479576 cites W1570226646 @default.
• W140479576 cites W1596846507 @default.
• W140479576 cites W1597771055 @default.
• W140479576 cites W1891400074 @default.
• W140479576 cites W1974052300 @default.
• W140479576 cites W2010490492 @default.
• W140479576 cites W2011706980 @default.
• W140479576 cites W2012067875 @default.
• W140479576 cites W2016203915 @default.
• W140479576 cites W2021597338 @default.
• W140479576 cites W2022277278 @default.
• W140479576 cites W2026822835 @default.
• W140479576 cites W2029449769 @default.
• W140479576 cites W2038531813 @default.
• W140479576 cites W2044691509 @default.
• W140479576 cites W2045235882 @default.
• W140479576 cites W2048829459 @default.
• W140479576 cites W2051673933 @default.
• W140479576 cites W2054099607 @default.
• W140479576 cites W2056445732 @default.
• W140479576 cites W2056548295 @default.
• W140479576 cites W2068302819 @default.
• W140479576 cites W2068838271 @default.
• W140479576 cites W2073231820 @default.
• W140479576 cites W2073788315 @default.
• W140479576 cites W2074719056 @default.
• W140479576 cites W2081753893 @default.
• W140479576 cites W2085574272 @default.
• W140479576 cites W2117061040 @default.
• W140479576 cites W2141260882 @default.
• W140479576 cites W2149580070 @default.
• W140479576 cites W2165365321 @default.
• W140479576 cites W2165453706 @default.
• W140479576 cites W2268145670 @default.
• W140479576 cites W2286687653 @default.
• W140479576 cites W2295565150 @default.
• W140479576 cites W2331216157 @default.
• W140479576 cites W2332452130 @default.
• W140479576 cites W2396258142 @default.
• W140479576 cites W2403880860 @default.
• W140479576 cites W2418585127 @default.
• W140479576 cites W2433386067 @default.
• W140479576 doi "https://doi.org/10.1182/blood.v87.2.648.bloodjournal872648" @default.
• W140479576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8555487" @default.
• W140479576 hasPublicationYear "1996" @default.
• W140479576 type Work @default.
• W140479576 sameAs 140479576 @default.
• W140479576 citedByCount "18" @default.
• W140479576 countsByYear W1404795762012 @default.
• W140479576 countsByYear W1404795762017 @default.
• W140479576 countsByYear W1404795762019 @default.
• W140479576 countsByYear W1404795762021 @default.
• W140479576 crossrefType "journal-article" @default.
• W140479576 hasAuthorship W140479576A5004473951 @default.
• W140479576 hasAuthorship W140479576A5015003674 @default.
• W140479576 hasAuthorship W140479576A5071812338 @default.
• W140479576 hasBestOaLocation W1404795761 @default.
• W140479576 hasConcept C12554922 @default.
• W140479576 hasConcept C126322002 @default.
• W140479576 hasConcept C131453863 @default.
• W140479576 hasConcept C134018914 @default.
• W140479576 hasConcept C170493617 @default.
• W140479576 hasConcept C181911157 @default.
• W140479576 hasConcept C185592680 @default.
• W140479576 hasConcept C2777292125 @default.
• W140479576 hasConcept C2778886182 @default.
• W140479576 hasConcept C4141045 @default.
• W140479576 hasConcept C55493867 @default.
• W140479576 hasConcept C66974803 @default.
• W140479576 hasConcept C71240020 @default.
• W140479576 hasConcept C71924100 @default.
• W140479576 hasConcept C83743174 @default.
• W140479576 hasConcept C86803240 @default.
• W140479576 hasConcept C89560881 @default.
• W140479576 hasConcept C95444343 @default.
• W140479576 hasConceptScore W140479576C12554922 @default.
• W140479576 hasConceptScore W140479576C126322002 @default.
• W140479576 hasConceptScore W140479576C131453863 @default.
• W140479576 hasConceptScore W140479576C134018914 @default.
• W140479576 hasConceptScore W140479576C170493617 @default.
• W140479576 hasConceptScore W140479576C181911157 @default.
• W140479576 hasConceptScore W140479576C185592680 @default.
• W140479576 hasConceptScore W140479576C2777292125 @default.
• W140479576 hasConceptScore W140479576C2778886182 @default.
• W140479576 hasConceptScore W140479576C4141045 @default.
• W140479576 hasConceptScore W140479576C55493867 @default.

• next