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- W140553772 abstract "Abstract Amyloidogenic proteins, characterized by their ability to form fibrilar aggregates with β-sheet configurations, play an important role in several neurodegenerative diseases, including Alzheimer’s disease. Although their exact mechanism of toxicity is not yet known, considerable experimental evidence, including planar lipid bilayer (BLM), calcium imaging, atomic force microscopy (AFM) and electron microscopy (EM), links small oligomers to membrane permeabilization, leading to cytotoxicity by loss of ionic homeostasis. A possible mechanism of this toxicity involves amyloids incorporated as pore-forming structures in the lipid environment of the membrane. Such pores produce stepwise increases in current across lipid bilayers in BLM data and can be recognized as small protrusions in AFM images. Unlike classic ion channels, these pores exhibit multiple ionic conductances and they have a variable number of subunits. Molecular dynamics (MD) simulations have provided atomistic models that capture the essential features of the pores. In these simulations, monomers adopt the U-shaped, β-strand-turn-β-strand motif as a general feature of amyloid organization." @default.
- W140553772 created "2016-06-24" @default.
- W140553772 creator A5006553652 @default.
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- W140553772 creator A5031961391 @default.
- W140553772 creator A5053680960 @default.
- W140553772 creator A5071084031 @default.
- W140553772 date "2014-01-01" @default.
- W140553772 modified "2023-09-23" @default.
- W140553772 title "Structure–Function Studies of Amyloid Pores in Alzheimer’s Disease as a Case Example of Neurodegenerative Diseases" @default.
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