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- W140574811 abstract "One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2′-angeloyl-3′-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The inhibitory activity of these three compounds and a deacylated form of archangelicin (4) on the nuclear factor of activated T cells (NFAT) signal transduction pathway was tested by NFAT-responsive luciferase reporter gene assay in cultured cells. Although 4 did not exhibit inhibitory activity on NFAT signaling, 1–3 exhibited dose-dependent inhibition with IC 50 values of 16.5 (1), 9.0 (2), and 9.2 (3) μM." @default.
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- W140574811 date "2014-12-01" @default.
- W140574811 modified "2023-10-16" @default.
- W140574811 title "Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway" @default.
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- W140574811 doi "https://doi.org/10.1177/1934578x1400901218" @default.
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