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- W140905372 abstract "Pigs surviving an African swine fever virus (ASFV) infection are protected against reinfection with the homologous virus strain. However, experiments with live or inactivated vaccines have not led to sufficient protection (1–5). Here we show data using inactivated, detergent-treated preparations originating from pigs infected with a highly virulent ASFV, rendering a fairly good survival rate (50–100%) of experimentally infected pigs. Also, virulent virus propagated in pig leucocyte cultures followed by inactivation conferred protection while 80–100% of control pigs died after infection. The use of complete Freund’s adjuvant improved the survival rate considerably. However, none of the preparations used as vaccine was able to prevent ASFV infection and replication. Consequently, the vaccinated pigs and thereafter experimentally infected proved to be virus carriers at least for 91 days. Virus persistence was demonstrated in vivo by infection of healthy pigs with blood sampled from carriers and in vitro by inoculation of pig leucocyte cultures. However, spontaneous virus transmission from surviving pigs to untreated in-contact pigs was not observed. Our serological results (ELISA, IIF, IE0P) indicate that protection is not based on antibodies to VP 73 but on factors preserved in inactivated antigens prepared from virulent virus." @default.
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- W140905372 date "1987-01-01" @default.
- W140905372 modified "2023-10-17" @default.
- W140905372 title "Approaches to Vaccination" @default.
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- W140905372 doi "https://doi.org/10.1007/978-1-4613-2343-3_10" @default.
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