Matches in SemOpenAlex for { <https://semopenalex.org/work/W140939216> ?p ?o ?g. }
- W140939216 endingPage "213" @default.
- W140939216 startingPage "189" @default.
- W140939216 abstract "Ischemic stroke develops when a major brain artery, most commonly the middle cerebral artery, is obstructed by an embolus or thrombosis and, consequently, blood flow in a restricted area of the brain is severely reduced. Even though animal research conducted on acute ischemic injury has revealed several pathophysiological cascades, which contribute to the enlargement of brain infarction, no major breakthroughs in developing clinically relevant stroke therapy have been achieved. There are several reasons for failed translation of successful basic research approaches into effective treatment modalities for stroke in humans (1). One important factor is that the animal models do not reflect well enough the ischemic damage in both permanent (no reperfusion) and transient (with reperfusion) ischemia in aged female and male victims, which may suffer from other age-related diseases, such as hypertension, diabetes, and Alzheimer’s disease (2). Another, even a more valid, fact is that the therapeutic time window for treating human stroke is delayed beyond the hours after the insult and, therefore, the pathophysiological events targeted pharmacologically need to occur several hours or days later (2). For these reasons, targeting mechanisms such as various glutamate receptors and calcium channels may not be considered for treatment of most of the stroke patients." @default.
- W140939216 created "2016-06-24" @default.
- W140939216 creator A5027124641 @default.
- W140939216 creator A5070430837 @default.
- W140939216 date "2003-01-01" @default.
- W140939216 modified "2023-09-23" @default.
- W140939216 title "Inflammation and Potential Anti-Inflammatory Approaches in Stroke" @default.
- W140939216 cites W1003794251 @default.
- W140939216 cites W133552068 @default.
- W140939216 cites W137838929 @default.
- W140939216 cites W1460931276 @default.
- W140939216 cites W1471466840 @default.
- W140939216 cites W1485896673 @default.
- W140939216 cites W1487068141 @default.
- W140939216 cites W1508621167 @default.
- W140939216 cites W1532538322 @default.
- W140939216 cites W1533808086 @default.
- W140939216 cites W1547412330 @default.
- W140939216 cites W1551533003 @default.
- W140939216 cites W1598875012 @default.
- W140939216 cites W1607300345 @default.
- W140939216 cites W1633340712 @default.
- W140939216 cites W1667686291 @default.
- W140939216 cites W1896626713 @default.
- W140939216 cites W1896893321 @default.
- W140939216 cites W1904875888 @default.
- W140939216 cites W1905938293 @default.
- W140939216 cites W1915946375 @default.
- W140939216 cites W1959529696 @default.
- W140939216 cites W1961175455 @default.
- W140939216 cites W1964187920 @default.
- W140939216 cites W1964780858 @default.
- W140939216 cites W1965658881 @default.
- W140939216 cites W1966565183 @default.
- W140939216 cites W1966735603 @default.
- W140939216 cites W1968589480 @default.
- W140939216 cites W1969138341 @default.
- W140939216 cites W1969530182 @default.
- W140939216 cites W1971153516 @default.
- W140939216 cites W1971792511 @default.
- W140939216 cites W1975594317 @default.
- W140939216 cites W1975603938 @default.
- W140939216 cites W1976385326 @default.
- W140939216 cites W1978487251 @default.
- W140939216 cites W1979090235 @default.
- W140939216 cites W1979961027 @default.
- W140939216 cites W1980793025 @default.
- W140939216 cites W1981947454 @default.
- W140939216 cites W1982592829 @default.
- W140939216 cites W1982652694 @default.
- W140939216 cites W1985315203 @default.
- W140939216 cites W1986643770 @default.
- W140939216 cites W1986751323 @default.
- W140939216 cites W1987331972 @default.
- W140939216 cites W1988218290 @default.
- W140939216 cites W1988536950 @default.
- W140939216 cites W1989271653 @default.
- W140939216 cites W1992256042 @default.
- W140939216 cites W1996604050 @default.
- W140939216 cites W1997253884 @default.
- W140939216 cites W1998200062 @default.
- W140939216 cites W2001230231 @default.
- W140939216 cites W2001751662 @default.
- W140939216 cites W2002427402 @default.
- W140939216 cites W2004085515 @default.
- W140939216 cites W2005726985 @default.
- W140939216 cites W2006289803 @default.
- W140939216 cites W2007281897 @default.
- W140939216 cites W2008424322 @default.
- W140939216 cites W2009160426 @default.
- W140939216 cites W2011349107 @default.
- W140939216 cites W2015517531 @default.
- W140939216 cites W2016469055 @default.
- W140939216 cites W2016602531 @default.
- W140939216 cites W2018022526 @default.
- W140939216 cites W2020303700 @default.
- W140939216 cites W2022378197 @default.
- W140939216 cites W2022526041 @default.
- W140939216 cites W2022959705 @default.
- W140939216 cites W2023396428 @default.
- W140939216 cites W2023849102 @default.
- W140939216 cites W2024476573 @default.
- W140939216 cites W2025392129 @default.
- W140939216 cites W2025461456 @default.
- W140939216 cites W2025638147 @default.
- W140939216 cites W2026717490 @default.
- W140939216 cites W2029200092 @default.
- W140939216 cites W2029883168 @default.
- W140939216 cites W2030485098 @default.
- W140939216 cites W2031906334 @default.
- W140939216 cites W2032731042 @default.
- W140939216 cites W2034226621 @default.
- W140939216 cites W2034827296 @default.
- W140939216 cites W2034882426 @default.
- W140939216 cites W2036380865 @default.
- W140939216 cites W2036717742 @default.
- W140939216 cites W2038781543 @default.
- W140939216 cites W2040088974 @default.