Matches in SemOpenAlex for { <https://semopenalex.org/work/W140965324> ?p ?o ?g. }
- W140965324 endingPage "674" @default.
- W140965324 startingPage "664" @default.
- W140965324 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and induce apoptosis in human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by cyclooxygenase-2 (COX-2) inhibition and how NSAIDs exert their anti-proliferative effects. We investigated the effects of NS-398 (a selective COX-2 inhibitor), indomethacin (a non-selective COX inhibitor) and aspirin on four human colorectal cancer cell lines (HT29.Fu, HCA-7, SW480 and HCT116). NS-398 completely inhibited proliferation, induced G1 arrest and promoted apoptosis in COX-2-expressing cells (HT29.Fu and HCA-7). However, indomethacin had similar effects on all cells, regardless of COX-2 expression. NS-398 also had anti-proliferative activity on COX-2-negative cell lines (SW480 and HCT116). Aspirin inhibited proliferation of all cell lines but did not induce apoptosis. Indomethacin decreased beta-catenin protein expression in all cells (unlike NS-398 or aspirin). NSAIDs act on human colorectal cancer cells via different mechanisms. Decreased beta-catenin protein expression may mediate the anti-proliferative effects of indomethacin." @default.
- W140965324 created "2016-06-24" @default.
- W140965324 creator A5044151978 @default.
- W140965324 creator A5059507305 @default.
- W140965324 creator A5069417785 @default.
- W140965324 date "2000-03-01" @default.
- W140965324 modified "2023-10-14" @default.
- W140965324 title "The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells" @default.
- W140965324 cites W1554815317 @default.
- W140965324 cites W1648593433 @default.
- W140965324 cites W1869980306 @default.
- W140965324 cites W1966861485 @default.
- W140965324 cites W1968561072 @default.
- W140965324 cites W1991731514 @default.
- W140965324 cites W1996212257 @default.
- W140965324 cites W2002404925 @default.
- W140965324 cites W2012810767 @default.
- W140965324 cites W2016507693 @default.
- W140965324 cites W2019418709 @default.
- W140965324 cites W2021415747 @default.
- W140965324 cites W2023200971 @default.
- W140965324 cites W2026307857 @default.
- W140965324 cites W2033042511 @default.
- W140965324 cites W2033387723 @default.
- W140965324 cites W2034679499 @default.
- W140965324 cites W2049821512 @default.
- W140965324 cites W2051686420 @default.
- W140965324 cites W2053086049 @default.
- W140965324 cites W2063284524 @default.
- W140965324 cites W2087224686 @default.
- W140965324 cites W2088404163 @default.
- W140965324 cites W2090535621 @default.
- W140965324 cites W2111303192 @default.
- W140965324 cites W2117858791 @default.
- W140965324 cites W2118252933 @default.
- W140965324 cites W2121889529 @default.
- W140965324 cites W2138200535 @default.
- W140965324 cites W2152619026 @default.
- W140965324 cites W2156470937 @default.
- W140965324 cites W2182692795 @default.
- W140965324 doi "https://doi.org/10.1016/s0959-8049(99)00333-0" @default.
- W140965324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10738133" @default.
- W140965324 hasPublicationYear "2000" @default.
- W140965324 type Work @default.
- W140965324 sameAs 140965324 @default.
- W140965324 citedByCount "248" @default.
- W140965324 countsByYear W1409653242012 @default.
- W140965324 countsByYear W1409653242013 @default.
- W140965324 countsByYear W1409653242014 @default.
- W140965324 countsByYear W1409653242015 @default.
- W140965324 countsByYear W1409653242016 @default.
- W140965324 countsByYear W1409653242017 @default.
- W140965324 countsByYear W1409653242018 @default.
- W140965324 countsByYear W1409653242019 @default.
- W140965324 countsByYear W1409653242020 @default.
- W140965324 countsByYear W1409653242021 @default.
- W140965324 countsByYear W1409653242022 @default.
- W140965324 countsByYear W1409653242023 @default.
- W140965324 crossrefType "journal-article" @default.
- W140965324 hasAuthorship W140965324A5044151978 @default.
- W140965324 hasAuthorship W140965324A5059507305 @default.
- W140965324 hasAuthorship W140965324A5069417785 @default.
- W140965324 hasConcept C121608353 @default.
- W140965324 hasConcept C126322002 @default.
- W140965324 hasConcept C181199279 @default.
- W140965324 hasConcept C185592680 @default.
- W140965324 hasConcept C190283241 @default.
- W140965324 hasConcept C202751555 @default.
- W140965324 hasConcept C2777628954 @default.
- W140965324 hasConcept C2779689624 @default.
- W140965324 hasConcept C2779707156 @default.
- W140965324 hasConcept C502942594 @default.
- W140965324 hasConcept C526805850 @default.
- W140965324 hasConcept C54355233 @default.
- W140965324 hasConcept C55493867 @default.
- W140965324 hasConcept C62112901 @default.
- W140965324 hasConcept C71924100 @default.
- W140965324 hasConcept C81885089 @default.
- W140965324 hasConcept C86803240 @default.
- W140965324 hasConcept C96232424 @default.
- W140965324 hasConcept C98274493 @default.
- W140965324 hasConceptScore W140965324C121608353 @default.
- W140965324 hasConceptScore W140965324C126322002 @default.
- W140965324 hasConceptScore W140965324C181199279 @default.
- W140965324 hasConceptScore W140965324C185592680 @default.
- W140965324 hasConceptScore W140965324C190283241 @default.
- W140965324 hasConceptScore W140965324C202751555 @default.
- W140965324 hasConceptScore W140965324C2777628954 @default.
- W140965324 hasConceptScore W140965324C2779689624 @default.
- W140965324 hasConceptScore W140965324C2779707156 @default.
- W140965324 hasConceptScore W140965324C502942594 @default.
- W140965324 hasConceptScore W140965324C526805850 @default.
- W140965324 hasConceptScore W140965324C54355233 @default.
- W140965324 hasConceptScore W140965324C55493867 @default.
- W140965324 hasConceptScore W140965324C62112901 @default.
- W140965324 hasConceptScore W140965324C71924100 @default.
- W140965324 hasConceptScore W140965324C81885089 @default.
- W140965324 hasConceptScore W140965324C86803240 @default.