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• W1410395591 startingPage "126" @default.
• W1410395591 abstract "Chlamydiae are taken up by host cells so efficiently that the process has been termed parasite-specified endocytosis by Byrne and Moulder. This chapter focuses upon the active interactions of chlamydiae with the host cell and covers the stage of development up to the division of reticulate bodies (RBs). Surprisingly, different mutant cell lines displayed unique patterns of susceptibility or resistance to different C. trachomatis serovars or to C. pneumoniae. Despite the difficulties of comparing studies between different chlamydial species or serovars, conditions, and cell types, there is sufficient evidence to suggest that individual chlamydiae are capable of utilizing different mechanisms for entry. Translocation of Tarp and its tyrosine phosphorylation appear to be one of the first means of communication with the host cell to actively subvert host processes for parasite purposes. Identification of the kinases mediating Tarp phosphorylation is an initial step in mapping the signal transduction networks initiated by C. trachomatis to establish residence within an intracellular niche. Endocytosed elementary bodies (EBs) are rapidly transported to the peri-Golgi region of the host cell and become fusogenic with Golgi-derived vesicles. The Inc proteins do not share structural similarities to eukaryotic proteins, except for SNARE-like motifs, and homology searches do not provide substantial clues about their function. An improved understanding of the complex interactions of the important pathogens with the host cell should provide great potential for improved chemotherapeu-tic and immunoprophylactic interventions." @default.
• W1410395591 created "2016-06-24" @default.
• W1410395591 creator A5051283258 @default.
• W1410395591 date "2014-04-30" @default.
• W1410395591 modified "2023-09-27" @default.
• W1410395591 title "Initial Interactions of Chlamydiae with the Host Cell" @default.
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