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- W1410501337 startingPage "309" @default.
- W1410501337 abstract "Multispecific, broad, and potent T cell responses have been correlated with viral clearance in hepatitis C virus (HCV) infection. However, the majority of infected patients develop chronic infection, suggesting that natural infection mostly leads to development of inefficient T cell immunity. Multiple mechanisms of immune modulation and evasion have been shown in HCV infection through various investigations. This study examined the generation and modulation of T cell responses against core and frameshift (F) proteins of HCV. A single immunization of mice with replication incompetent recombinant adenovirus vectors encoding for F or core antigens induces poor T cell responses and leads to generation of CD4+ and CD8+ T cells with low granzyme B (GrB) expression. These T cells have impaired GrB enzyme activity and are unable to kill peptide loaded target cells. The low intracellular expression of GrB is not due to degranulation of cytotoxic granules containing cytotoxic T cells. Addition of exogenous IL-2 in in vitro cultures leads to partial recovery of GrB production, whereas immunization with the Toll-like receptor (TLR) agonist poly I:C leads to complete restoration of GrB expression in both CD4+ and CD8+ T cells. Thus, a possible new strategy of T cell modulation is recognized wherein effector T cells are caused to be dysfunctional by HCV-derived antigens F or core, and strategies are also delineated to overcome this dysfunction. These studies are important in the investigation of prophylactic vaccine and immunotherapy strategies for HCV infection." @default.
- W1410501337 created "2016-06-24" @default.
- W1410501337 creator A5001728683 @default.
- W1410501337 creator A5013000959 @default.
- W1410501337 creator A5033382206 @default.
- W1410501337 creator A5046152779 @default.
- W1410501337 creator A5067414632 @default.
- W1410501337 creator A5083700304 @default.
- W1410501337 date "2015-07-01" @default.
- W1410501337 modified "2023-09-24" @default.
- W1410501337 title "Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-γ: A Potential New Strategy for Immune Evasion in HCV Infection" @default.
- W1410501337 cites W1480428089 @default.
- W1410501337 cites W1566992315 @default.
- W1410501337 cites W1586958533 @default.
- W1410501337 cites W1593341627 @default.
- W1410501337 cites W1602273859 @default.
- W1410501337 cites W1628217135 @default.
- W1410501337 cites W1645159332 @default.
- W1410501337 cites W175479904 @default.
- W1410501337 cites W1853205566 @default.
- W1410501337 cites W1937536036 @default.
- W1410501337 cites W1958134254 @default.
- W1410501337 cites W1966934571 @default.
- W1410501337 cites W1969728880 @default.
- W1410501337 cites W1973165481 @default.
- W1410501337 cites W1978373343 @default.
- W1410501337 cites W1981136135 @default.
- W1410501337 cites W1984007630 @default.
- W1410501337 cites W1987967078 @default.
- W1410501337 cites W1991743610 @default.
- W1410501337 cites W1992109850 @default.
- W1410501337 cites W1993617345 @default.
- W1410501337 cites W1994236426 @default.
- W1410501337 cites W1994640744 @default.
- W1410501337 cites W1997734842 @default.
- W1410501337 cites W1999587028 @default.
- W1410501337 cites W1999755878 @default.
- W1410501337 cites W2000411347 @default.
- W1410501337 cites W2000952771 @default.
- W1410501337 cites W2001093199 @default.
- W1410501337 cites W2006190883 @default.
- W1410501337 cites W2006309458 @default.
- W1410501337 cites W2010346178 @default.
- W1410501337 cites W2012180137 @default.
- W1410501337 cites W2019969899 @default.
- W1410501337 cites W2022057836 @default.
- W1410501337 cites W2025559871 @default.
- W1410501337 cites W2026208522 @default.
- W1410501337 cites W2028207476 @default.
- W1410501337 cites W2034116082 @default.
- W1410501337 cites W2044336698 @default.
- W1410501337 cites W2049115723 @default.
- W1410501337 cites W2050466666 @default.
- W1410501337 cites W2052196168 @default.
- W1410501337 cites W2052563206 @default.
- W1410501337 cites W2053536599 @default.
- W1410501337 cites W2054131990 @default.
- W1410501337 cites W2056587932 @default.
- W1410501337 cites W2070598138 @default.
- W1410501337 cites W2071679112 @default.
- W1410501337 cites W2074229472 @default.
- W1410501337 cites W2076361525 @default.
- W1410501337 cites W2077301497 @default.
- W1410501337 cites W2077789967 @default.
- W1410501337 cites W2079309756 @default.
- W1410501337 cites W2088511177 @default.
- W1410501337 cites W2089829321 @default.
- W1410501337 cites W2093487297 @default.
- W1410501337 cites W2093542694 @default.
- W1410501337 cites W2100137871 @default.
- W1410501337 cites W2103338170 @default.
- W1410501337 cites W2104357791 @default.
- W1410501337 cites W2106132583 @default.
- W1410501337 cites W2107095788 @default.
- W1410501337 cites W2109734100 @default.
- W1410501337 cites W2122392232 @default.
- W1410501337 cites W2122459539 @default.
- W1410501337 cites W2124778275 @default.
- W1410501337 cites W2126072190 @default.
- W1410501337 cites W2126223489 @default.
- W1410501337 cites W2132048270 @default.
- W1410501337 cites W2137929296 @default.
- W1410501337 cites W2138464364 @default.
- W1410501337 cites W2139103918 @default.
- W1410501337 cites W2141984893 @default.
- W1410501337 cites W2150983148 @default.
- W1410501337 cites W2153164882 @default.
- W1410501337 cites W2153346747 @default.
- W1410501337 cites W2159125893 @default.
- W1410501337 cites W2159131506 @default.
- W1410501337 cites W2159974321 @default.
- W1410501337 cites W2169757199 @default.
- W1410501337 cites W2171324025 @default.
- W1410501337 cites W2333452860 @default.
- W1410501337 cites W2791218690 @default.
- W1410501337 doi "https://doi.org/10.1089/vim.2015.0009" @default.
- W1410501337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26133045" @default.
- W1410501337 hasPublicationYear "2015" @default.