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- W1410543535 abstract "This article reviews data providing new insight into the trajectory of response and maintenance of response of atomoxetine in the treatment of child and adult attention-deficit hyperactivity disorder (ADHD). This nonsystematic review includes: onset of action and duration of effect, response rate, effect size, time to optimal response and norepinephrine transporter blockade biomarker data. Atomoxetine can have an onset of action within 1-2 weeks of starting treatment, but there is an incrementally increasing response for up to 24 weeks or longer. Responder rates and effect sizes are similar to methylphenidate. Upon treatment discontinuation, relapse rates are lower than expected. In adults, 50% maintain their response for at least 6 months after stopping atomoxetine, following 6 months of treatment. Single-dose atomoxetine can provide 24-hour efficacy, despite a 5-hour plasma half-life. Hypotheses can be generated relating to neuroadaptive changes, to explain these findings. Atomoxetine has a trajectory of response that is incremental over a long period of time, with a greater than expected maintenance of response. This has implications for physician atomoxetine dosing and efficacy assessment, patient education and outcomes, and for clinical trial design and assessment of comparative efficacy with stimulant medications." @default.
- W1410543535 created "2016-06-24" @default.
- W1410543535 creator A5036999043 @default.
- W1410543535 creator A5074167012 @default.
- W1410543535 date "2015-09-08" @default.
- W1410543535 modified "2023-09-30" @default.
- W1410543535 title "Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients" @default.
- W1410543535 cites W1535576495 @default.
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- W1410543535 cites W1966204370 @default.
- W1410543535 cites W1966900123 @default.
- W1410543535 cites W1968639372 @default.
- W1410543535 cites W1970966565 @default.
- W1410543535 cites W1973824257 @default.
- W1410543535 cites W1981980657 @default.
- W1410543535 cites W1989432790 @default.
- W1410543535 cites W1993327116 @default.
- W1410543535 cites W1999037665 @default.
- W1410543535 cites W1999725272 @default.
- W1410543535 cites W2001389318 @default.
- W1410543535 cites W2012949133 @default.
- W1410543535 cites W2016483680 @default.
- W1410543535 cites W2020433416 @default.
- W1410543535 cites W2022516563 @default.
- W1410543535 cites W2023169310 @default.
- W1410543535 cites W2025431637 @default.
- W1410543535 cites W2027451644 @default.
- W1410543535 cites W2028153389 @default.
- W1410543535 cites W2028637191 @default.
- W1410543535 cites W2035761153 @default.
- W1410543535 cites W2040977256 @default.
- W1410543535 cites W2043552268 @default.
- W1410543535 cites W2044253418 @default.
- W1410543535 cites W2045618085 @default.
- W1410543535 cites W2045688529 @default.
- W1410543535 cites W2048386311 @default.
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- W1410543535 cites W2077367843 @default.
- W1410543535 cites W2078752612 @default.
- W1410543535 cites W2091646494 @default.
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- W1410543535 cites W2141784450 @default.
- W1410543535 cites W2144633011 @default.
- W1410543535 cites W2151526332 @default.
- W1410543535 cites W2155681415 @default.
- W1410543535 cites W2155877143 @default.
- W1410543535 cites W2157382328 @default.
- W1410543535 cites W2162753002 @default.
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- W1410543535 cites W2166748612 @default.
- W1410543535 cites W2171147935 @default.
- W1410543535 cites W2408441620 @default.
- W1410543535 cites W4236486344 @default.
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- W1410543535 doi "https://doi.org/10.1177/0269881115602489" @default.
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