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• W1411119344 endingPage "1696" @default.
• W1411119344 startingPage "1690" @default.
• W1411119344 abstract "The crystal structure of a synthetic peptide representing the major antigenic loop of foot-and-mouth disease virus (FMDV), complexed with the Fab fragment of a neutralizing monoclonal antibody raised against the virus, has been determined at 2.8 A resolution. The peptide shows a high degree of internal structure with a nearly cyclic conformation. The conserved Arg-Gly-Asp motif, involved in the viral attachment of aphtoviruses to cells, participates directly in the interaction with several complementarity determining regions of the antibody molecule. The Arg-Gly-Asp triplet shows the same open turn conformation found in the reduced form of FMDV of another serotype and also in integrin binding proteins. The observed interactions provide a molecular interpretation of the amino acid replacements observed to occur in mutants resistant to neutralization by this antibody. The structure also suggests a number of restrictions to variation within the epitope which are imposed to keep the Arg-Gly-Asp motif in its functional conformation." @default.
• W1411119344 created "2016-06-24" @default.
• W1411119344 creator A5007990086 @default.
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• W1411119344 creator A5091216330 @default.
• W1411119344 date "1995-04-01" @default.
• W1411119344 modified "2023-10-14" @default.
• W1411119344 title "Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction." @default.
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• W1411119344 doi "https://doi.org/10.1002/j.1460-2075.1995.tb07158.x" @default.
• W1411119344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/398262" @default.
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