FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1412912502> ?p ?o ?g. }

• W1412912502 abstract "Controlled drug delivery is a key topic in modern pharmacotherapy, where controlled drug delivery devices are required to prolong the period of release, maintain a constant release rate, or release the drug with a predetermined release profile. In the pharmaceutical industry, the development process of a controlled drug delivery device may be facilitated enormously by the mathematical modelling of drug release mechanisms, directly decreasing the number of necessary experiments. Such mathematical modelling is difficult because several mechanisms are involved during the drug release process. The main drug release mechanisms of a controlled release device are based on the device’s physiochemical properties, and include diffusion, swelling and erosion.In this thesis, four controlled drug delivery models are investigated. These four models selectively involve the solvent penetration into the polymeric device, the swelling of the polymer, the polymer erosion and the drug diffusion out of the device but all share two common key features. The first is that the solvent penetration into the polymer causes the transition of the polymer from a glassy state into a rubbery state. The interface between the two states of the polymer is modelled as a moving boundary and the speed of this interface is governed by a kinetic law. The second feature is that drug diffusion only happens in the rubbery region of the polymer, with a nonlinear diffusion coefficient which is dependent on the concentration of solvent. These models are analysed by using both formal asymptotics and numerical computation, where front-fixing methods and the method of lines with finite difference approximations are used to solve these models numerically. This numerical scheme is conservative, accurate and easily implemented to the moving boundary problems and is thoroughly explained in Section 3.2. From the small time asymptotic analysis in Sections 5.3.1, 6.3.1 and 7.2.1, these models exhibit the non-Fickian behaviour referred to as Case II diffusion, and an initial constant rate of drug release which is appealing to the pharmaceutical industry because this indicates zeroorder release. The numerical results of the models qualitatively confirms the experimental behaviour identified in the literature. The knowledge obtained from investigating these models can help to develop more complex multi-layered drug delivery devices in order to achieve sophisticated drug release profiles. A multi-layer matrix tablet, which consists of a number of polymer layers designed to provide sustainable and constant drug release or bimodal drug release, is also discussed in this research.The moving boundary problem describing the solvent penetration into the polymer also arises in melting and freezing problems which have been modelled as the classical onephase Stefan problem. The classical one-phase Stefan problem has unrealistic singularities existed in the problem at the complete melting time. Hence we investigate the effect of including the kinetic undercooling to the melting problem and this problem is called the one-phase Stefan problem with kinetic undercooling. Interestingly we discover the unrealistic singularities existed in the classical one-phase Stefan problem at the complete melting time are regularised and also find out the small time behaviour of the one-phase Stefan problem with kinetic undercooling is different to the classical one-phase Stefan problem from the small time asymptotic analysis in Section 3.3. In the case of melting very small particles, it is known that surface tension effects are important. The effect of including the surface tension to the melting problem for nanoparticles (no kinetic undercooling) has been investigated in the past, however the one-phase Stefan problem with surface tension exhibits finite-time blow-up. Therefore we investigate the effect of including both the surface tension and kinetic undercooling to the melting problem for nanoparticles and find out the the solution continues to exist until complete melting.The investigation of including kinetic undercooling and surface tension to the melting problems reveals more insight into the regularisations of unphysical singularities in the classical one-phase Stefan problem. This investigation gives a better understanding of melting a particle, and contributes to the current body of knowledge related to melting and freezing due to heat conduction." @default.
• W1412912502 created "2016-06-24" @default.
• W1412912502 creator A5042972392 @default.
• W1412912502 date "2012-01-01" @default.
• W1412912502 modified "2023-09-28" @default.
• W1412912502 title "Mathematical modelling of controlled drug release from polymer micro-spheres : incorporating the effects of swelling, diffusion and dissolution via moving boundary problems" @default.
• W1412912502 hasPublicationYear "2012" @default.
• W1412912502 type Work @default.
• W1412912502 sameAs 1412912502 @default.
• W1412912502 citedByCount "1" @default.
• W1412912502 countsByYear W14129125022013 @default.
• W1412912502 crossrefType "journal-article" @default.
• W1412912502 hasAuthorship W1412912502A5042972392 @default.
• W1412912502 hasConcept C121332964 @default.
• W1412912502 hasConcept C127413603 @default.
• W1412912502 hasConcept C136229726 @default.
• W1412912502 hasConcept C159985019 @default.
• W1412912502 hasConcept C163588942 @default.
• W1412912502 hasConcept C171250308 @default.
• W1412912502 hasConcept C178790620 @default.
• W1412912502 hasConcept C185592680 @default.
• W1412912502 hasConcept C192562407 @default.
• W1412912502 hasConcept C2778540859 @default.
• W1412912502 hasConcept C2779820397 @default.
• W1412912502 hasConcept C3017618536 @default.
• W1412912502 hasConcept C33923547 @default.
• W1412912502 hasConcept C41008148 @default.
• W1412912502 hasConcept C42475967 @default.
• W1412912502 hasConcept C521977710 @default.
• W1412912502 hasConcept C56739046 @default.
• W1412912502 hasConcept C68710425 @default.
• W1412912502 hasConcept C69357855 @default.
• W1412912502 hasConcept C80107235 @default.
• W1412912502 hasConcept C88380143 @default.
• W1412912502 hasConcept C97355855 @default.
• W1412912502 hasConceptScore W1412912502C121332964 @default.
• W1412912502 hasConceptScore W1412912502C127413603 @default.
• W1412912502 hasConceptScore W1412912502C136229726 @default.
• W1412912502 hasConceptScore W1412912502C159985019 @default.
• W1412912502 hasConceptScore W1412912502C163588942 @default.
• W1412912502 hasConceptScore W1412912502C171250308 @default.
• W1412912502 hasConceptScore W1412912502C178790620 @default.
• W1412912502 hasConceptScore W1412912502C185592680 @default.
• W1412912502 hasConceptScore W1412912502C192562407 @default.
• W1412912502 hasConceptScore W1412912502C2778540859 @default.
• W1412912502 hasConceptScore W1412912502C2779820397 @default.
• W1412912502 hasConceptScore W1412912502C3017618536 @default.
• W1412912502 hasConceptScore W1412912502C33923547 @default.
• W1412912502 hasConceptScore W1412912502C41008148 @default.
• W1412912502 hasConceptScore W1412912502C42475967 @default.
• W1412912502 hasConceptScore W1412912502C521977710 @default.
• W1412912502 hasConceptScore W1412912502C56739046 @default.
• W1412912502 hasConceptScore W1412912502C68710425 @default.
• W1412912502 hasConceptScore W1412912502C69357855 @default.
• W1412912502 hasConceptScore W1412912502C80107235 @default.
• W1412912502 hasConceptScore W1412912502C88380143 @default.
• W1412912502 hasConceptScore W1412912502C97355855 @default.
• W1412912502 hasLocation W14129125021 @default.
• W1412912502 hasOpenAccess W1412912502 @default.
• W1412912502 hasPrimaryLocation W14129125021 @default.
• W1412912502 hasRelatedWork W1570555520 @default.
• W1412912502 hasRelatedWork W1648348299 @default.
• W1412912502 hasRelatedWork W2024640959 @default.
• W1412912502 hasRelatedWork W2032618578 @default.
• W1412912502 hasRelatedWork W2033506052 @default.
• W1412912502 hasRelatedWork W2060556058 @default.
• W1412912502 hasRelatedWork W2061245906 @default.
• W1412912502 hasRelatedWork W2062310403 @default.
• W1412912502 hasRelatedWork W2068353892 @default.
• W1412912502 hasRelatedWork W2069532070 @default.
• W1412912502 hasRelatedWork W2115294363 @default.
• W1412912502 hasRelatedWork W2143197304 @default.
• W1412912502 hasRelatedWork W2177399444 @default.
• W1412912502 hasRelatedWork W2285267600 @default.
• W1412912502 hasRelatedWork W2301455801 @default.
• W1412912502 hasRelatedWork W2567255627 @default.
• W1412912502 hasRelatedWork W291393588 @default.
• W1412912502 hasRelatedWork W2915711412 @default.
• W1412912502 hasRelatedWork W2937588488 @default.
• W1412912502 hasRelatedWork W3013296284 @default.
• W1412912502 isParatext "false" @default.
• W1412912502 isRetracted "false" @default.
• W1412912502 magId "1412912502" @default.
• W1412912502 workType "article" @default.