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- W141344346 abstract "Publisher Summary The recombinant DNA technology is used to understand the tissue-specific, developmentally regulated expression of the four different glycoprotein hormones: chorionic gonadotropin (CG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). The isolation of a full-length cDNA encoding the common α subunit demonstrates that there is a single human gene for this protein, expressed in the placenta for production of hCG and in the pituitary for the production of hLH, hFSH, and hTSH. From this, it is concluded that the control for the expression of glycoprotein hormones probably resides in the β subunit genes. The isolation of a full-length cDNA encoding the β subunit of hCG allows to isolate the full human complement of seven hCG β subunit genes or pseudogenes and, by cross-hybridization, the single β hLH gene. The β hLH gene is linked to at least three of the β hCG genes, and together, they show a complex organization of inverted and tandem pairs. In the analysis of independently isolated β hCG cDNA clones and from transfection of six of the seven β hCG genes into mammalian tissue culture cells, it was found that only three of the seven hCG genes are expressed. From a comparison of the nucleotide sequence of two of the β hCG genes and of the single β hLH gene, β hCG is shown to arise from β hLH by a series of selected changes with very little neutral drift." @default.
- W141344346 created "2016-06-24" @default.
- W141344346 creator A5017474438 @default.
- W141344346 creator A5066137751 @default.
- W141344346 date "1984-01-01" @default.
- W141344346 modified "2023-09-25" @default.
- W141344346 title "Structure, Expression, and Evolution of the Genes for the Human Glycoprotein Hormones" @default.
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- W141344346 doi "https://doi.org/10.1016/b978-0-12-571140-1.50006-2" @default.
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