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- W1413700825 abstract "This chapter describes the synthesis of biopterin, neopterin, and analogs. Polyhydroxyalkylpterins are prepared by condensation of 2, 4,5-triamino- 6-hydroxypyrimidine with aldoses in the presence of hydrazine. The use of 5-deoxy-L-arabinose gives rise to the formation of biopterin [2-amino-4-hydroxy-6-(L-erythro-1, 2-dihydroxypropyl) pteridine. Biopterin in its reduced form function as a cofactor in various mixed-function oxidase reactions. As a byproduct of this condensation, the isomeric 7-biopterin [2-amino-4-hydroxy-7-(L-erythro-1, 2-dihydroxypropyl) pteridine] is formed in an appreciable amount. Separation and purification of biopterin and 7-biopterin is achieved by cation-exchange chromatography on phosphorylated cellulose (P-cellulose). Neopterin, aminobiopterin, and the optical isomers of biopterin and neopterin are prepared in pure form by using the pentoses. The capacity of P-cellulose is high and permits the use of small-volume columns; the retention volumes of the isomers exhibit a satisfactory difference. The compounds are characterized by their UV spectra; nuclear magnetic resonance data for the amino analogs are also provided. The behavior of the substances in several solvent systems is summarized." @default.
- W1413700825 created "2016-06-24" @default.
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- W1413700825 date "1971-01-01" @default.
- W1413700825 modified "2023-09-27" @default.
- W1413700825 title "[181] Synthesis of biopterin, neopterin, and analogs" @default.
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- W1413700825 doi "https://doi.org/10.1016/s0076-6879(71)18138-4" @default.
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