FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1413942203> ?p ?o ?g. }

• W1413942203 abstract "Purpose: Post-irradiation cerebral necrosis (PICN) is a severe late effect that can Result from brain cancers treatment using radiation therapy. The purpose of this study was to compare the treatment plans and predicted risk of PICN after volumetric modulated arc therapy (VMAT) to the risk after passively scattered proton therapy (PSPT) and intensity modulated proton therapy (IMPT) in a cohort of pediatric patients. Methods: Thirteen pediatric patients with varying age and sex were selected for this study. A clinical treatment volume (CTV) was constructed for 8 glioma patients and 5 ependymoma patients. Prescribed dose was 54 Gy over 30 fractions to the planning volume. Dosimetric endpoints were compared between VMAT and proton plans. The normal tissue complication probability (NTCP) following VMAT and proton therapy planning was also calculated using PICN as the biological endpoint. Sensitivity tests were performed to determine if predicted risk of PICN was sensitive to positional errors, proton range errors and selection of risk models. Results: Both PSPT and IMPT plans resulted in a significant increase in the maximum dose and reduction in the total brain volume irradiated to low doses compared with the VMAT plans. The average ratios of NTCP between PSPT and VMAT were 0.56 and 0.38 for glioma and ependymoma patients respectively and the average ratios of NTCP between IMPT and VMAT were 0.67 and 0.68 for glioma and ependymoma plans respectively. Sensitivity test revealed that predicted ratios of risk were insensitive to range and positional errors but varied with risk model selection. Conclusion: Both PSPT and IMPT plans resulted in a decrease in the predictive risk of necrosis for the pediatric plans studied in this work. Sensitivity analysis upheld the qualitative findings of the risk models used in this study, however more accurate models that take into account dose and volume are needed." @default.
• W1413942203 created "2016-06-24" @default.
• W1413942203 creator A5001234563 @default.
• W1413942203 creator A5024256036 @default.
• W1413942203 creator A5087473923 @default.
• W1413942203 creator A5088945228 @default.
• W1413942203 date "2015-06-01" @default.
• W1413942203 modified "2023-09-23" @default.
• W1413942203 title "SU-E-T-628: Predicted Risk of Post-Irradiation Cerebral Necrosis in Pediatric Brain Cancer Patients: A Treatment Planning Comparison of Proton Vs. Photon Therapy" @default.
• W1413942203 doi "https://doi.org/10.1118/1.4924991" @default.
• W1413942203 hasPublicationYear "2015" @default.
• W1413942203 type Work @default.
• W1413942203 sameAs 1413942203 @default.
• W1413942203 citedByCount "0" @default.
• W1413942203 crossrefType "journal-article" @default.
• W1413942203 hasAuthorship W1413942203A5001234563 @default.
• W1413942203 hasAuthorship W1413942203A5024256036 @default.
• W1413942203 hasAuthorship W1413942203A5087473923 @default.
• W1413942203 hasAuthorship W1413942203A5088945228 @default.
• W1413942203 hasConcept C126838900 @default.
• W1413942203 hasConcept C201645570 @default.
• W1413942203 hasConcept C2778227246 @default.
• W1413942203 hasConcept C2779244869 @default.
• W1413942203 hasConcept C2781432949 @default.
• W1413942203 hasConcept C2989005 @default.
• W1413942203 hasConcept C502942594 @default.
• W1413942203 hasConcept C509974204 @default.
• W1413942203 hasConcept C71924100 @default.
• W1413942203 hasConceptScore W1413942203C126838900 @default.
• W1413942203 hasConceptScore W1413942203C201645570 @default.
• W1413942203 hasConceptScore W1413942203C2778227246 @default.
• W1413942203 hasConceptScore W1413942203C2779244869 @default.
• W1413942203 hasConceptScore W1413942203C2781432949 @default.
• W1413942203 hasConceptScore W1413942203C2989005 @default.
• W1413942203 hasConceptScore W1413942203C502942594 @default.
• W1413942203 hasConceptScore W1413942203C509974204 @default.
• W1413942203 hasConceptScore W1413942203C71924100 @default.
• W1413942203 hasLocation W14139422031 @default.
• W1413942203 hasOpenAccess W1413942203 @default.
• W1413942203 hasPrimaryLocation W14139422031 @default.
• W1413942203 hasRelatedWork W1589286959 @default.
• W1413942203 hasRelatedWork W1970262956 @default.
• W1413942203 hasRelatedWork W1979043984 @default.
• W1413942203 hasRelatedWork W2151071551 @default.
• W1413942203 hasRelatedWork W2471190107 @default.
• W1413942203 hasRelatedWork W2516472043 @default.
• W1413942203 hasRelatedWork W2898026474 @default.
• W1413942203 hasRelatedWork W2945282835 @default.
• W1413942203 hasRelatedWork W2945552838 @default.
• W1413942203 hasRelatedWork W2965951074 @default.
• W1413942203 hasRelatedWork W2969024471 @default.
• W1413942203 hasRelatedWork W2972719070 @default.
• W1413942203 hasRelatedWork W2999701107 @default.
• W1413942203 hasRelatedWork W3027663050 @default.
• W1413942203 hasRelatedWork W3033179719 @default.
• W1413942203 hasRelatedWork W3094573322 @default.
• W1413942203 hasRelatedWork W3147634793 @default.
• W1413942203 hasRelatedWork W3174623975 @default.
• W1413942203 hasRelatedWork W3182397854 @default.
• W1413942203 hasRelatedWork W3198943819 @default.
• W1413942203 isParatext "false" @default.
• W1413942203 isRetracted "false" @default.
• W1413942203 magId "1413942203" @default.
• W1413942203 workType "article" @default.