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- W1414301305 abstract "Transcripts encoding the Lyn kinase were first identified by virtue of sequence relatedness to Yes. Fyn is a typical Src family nonreceptor PTK. The LYN gene is expressed in hematopoietic cells, primarily myeloid cells and B lymphocytes. Two forms of the protein, the products of translation of alternatively spliced transcripts differing by only 21 codons, are expressed simultaneously. The Lyn kinase associates with the immunoglobulin complex on B-cell surfaces and is believed to participate in activating the phosphatidylinositol-3-kinase. A possible interaction with the lL-2 and IL-3 receptors in some transformed cell lines has also been reported. In domain structure of PK, myristoylation occurs at the N-terminal glycine. There are four domains, as in other Src family kinases. The two isoforms differ in their SH3 domains; no functional differences have yet been attributed to these products of alternatively spliced transcripts. The SH3 and SH2 domains have been defined by conventional sequence comparisons, as has the SH1 (kinase) domain. Little information is available regarding posttranslational modifications of Lyn. Lyn activity is assayed in immunoprecipitates by autophosphorylation, or by phosphorylation of exogenously added, denatured enolase." @default.
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- W1414301305 date "1995-01-01" @default.
- W1414301305 modified "2023-09-25" @default.
- W1414301305 title "Lyn" @default.
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- W1414301305 doi "https://doi.org/10.1016/b978-012324719-3/50143-6" @default.
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