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• W141434080 abstract "It is very common for critically ill patients to be placed on high concentrations of oxygen for prolonged periods of time despite the fact that multiple studies have linked hyperoxia to lung injury in animals and perhaps man. As early as the 19th century it was known that oxygen is both essential for life and capable of injury as well. Although oxygen has the ability to injure several organ systems in man, its toxicity to the lungs is the best described. Oxygen toxicity to the lung has been studied extensively both in man and animals from the molecular level to the bedside, and the nature of its pathogenesis has previously been well characterized. In recent years, however, new data have emerged further expanding our knowledge of the pathophysiology of hyperoxic lung injury and the many diverse ways cells and tissues protect themselves from injury. It has long been known that oxygen causes direct tissue injury via the production of toxic reactive oxygen species (ROS). It is now also known that oxygen toxicity involves a number of other secondary factors including inflammatory cells, lipid mediators, and cytokines. In this chapter we will review what is currently known about the pathophysiology of hyperoxic lung injury as well as the data from human studies which characterize its effects in man. Finally, we will review some of the newer studies showing mechanisms of both endogenous and exogenous protection from hyperoxic lung injury which may have significant implications for future therapy and prevention." @default.
• W141434080 created "2016-06-24" @default.
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• W141434080 date "2000-01-01" @default.
• W141434080 modified "2023-09-30" @default.
• W141434080 title "Pulmonary Oxygen Toxicity in Man: Emerging Concepts in Pathogenesis and Prevention" @default.
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• W141434080 doi "https://doi.org/10.1007/978-3-662-13455-9_18" @default.
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