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• W141536596 abstract "During the past two decades, it has been well establishedthat vascular endothelium plays a pivotal role in maintainingvascular tone. It is of interest to note that the initialdiscovery of endothelial-dependent vasodilation by Furch-gott and Zawadzki (1) in 1980 occurred as a result of anaccidental finding due to an error of a research assistant. Intheir seminal paper, Furchgott and Zawadzki (1) reportedthat the thoracic aorta and a variety of other arteriesobtained from experimental animals exhibited relaxation inresponse to acetylcholine (ACh) only if the endotheliumwas intact (1). Subsequent investigations in their laboratoryrevealed that ACh stimulated the release of a diffusiblerelaxing substance from endothelial cells, later referred to asendothelium-derived relaxing factor (EDRF) (2). It was notuntil 1986 that Furchgott and coworkers, as well as Ignarroet al., independently proposed that EDRF is nitric oxide(NO) (3,4).The discovery of NO and other mediators released by theendothelium has subsequently led to tremendous interest ofinvestigators in this field throughout the world. During thelast 10 years, we have seen an exponential growth in ourknowledge and understanding of the role of endothelialdysfunction in a variety of cardiovascular conditions (5–20).It has been demonstrated that endothelial dysfunctionmight indeed be the initiating event in the process ofatherosclerosis and vascular remodeling, which subsequentlyleads to clinical coronary artery disease (CAD) (21,22).Accordingly, there has been an ongoing, aggressive searchfor therapeutic choices suitable for reversing endothelialdysfunction with the hope that such therapeutic interven-tion, if instituted early in the course of the disease, mightprevent and/or modify the subsequent risk of clinical diseaseand related cardiac events (6–25). The magnitude of inter-est in this area can be best illustrated by the large number ofarticles published on the endothelium and related issuesfrom 1997 to 1999. A recent Medline search revealed that,on average, during this period in excess of 1,200 articles peryear were published in the English language regardinginvestigations dealing with vascular endothelium in humans,and, of these, nearly 550 articles specifically describe theeffects of various cardiovascular therapeutic agents on theendothelium. Indeed, the time has come to recognize theendothelium as an important and new target for cardiovas-cular therapeutics. The article by Anderson et al. (26) in this" @default.
• W141536596 created "2016-06-24" @default.
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• W141536596 date "2000-01-01" @default.
• W141536596 modified "2023-09-29" @default.
• W141536596 title "Endothelium: a new target for cardiovascular therapeutics∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology." @default.
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• W141536596 doi "https://doi.org/10.1016/s0735-1097(99)00536-7" @default.
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