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- W1416148015 abstract "Changes in iron metabolism in prostate cancer are not understood. We address the hypothesis that more aggressive prostate cancers exhibit markers of higher acquisition and intracellular retention of iron. Analysis of Oncomine, a public microarray database demonstrated elevation in mRNA gene expression in high grade tumors (Gleason scores 8-10) when compared to low grade tumors (scores 4-6) for several genes involved in iron metabolism, including Transferrin Receptor 1 (TfR1; 7 out of 11 databases), Ferritin Light Chain (FTL; 6 of 6) and Ferritin Heavy Chain (FTH; 6 of 8). The differences were statistically significant (p<0.05) in 4/7, 3/6, and 1/8 databases respectively (Welch t-test or Wilcoxon rank-sum test). Meta-analysis by Z-transform test showed significant global p-values for TfR1 and FTL, but not for FTH. TfR1 over expression in more aggressive tumors was confirmed by immunohistochemistry by comparing prostatectomy samples in a 400 cases outocomes-based tissue microarray (TMA) built by the Cooperative Prostate Cancer Tissue Resource. The recurrence group had higher TfR1 intensity levels (p<=0.04). In a previous publication we showed that iron levels were decreased in areas surrounding tumors that had poorer prognosis. Others have shown that within the tumor itself, iron levels are increased and high Gleason grade tumors have the highest levels. Overall our data suggest that 1) iron is less available to prostate cancer cells with worse prognosis, and 2) TfR1 and FTL overexpression in more aggressive tumors may contribute to the ability to accumulate iron." @default.
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- W1416148015 date "2015-04-01" @default.
- W1416148015 modified "2023-10-18" @default.
- W1416148015 title "Iron Metabolism and Prostate Cancer Aggressiveness: A Meta‐Analysis of Gene Expression Microarray Datasets" @default.
- W1416148015 doi "https://doi.org/10.1096/fasebj.29.1_supplement.284.9" @default.
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