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- W1417369868 abstract "This chapter focuses on the methodology in purification of recombinant autoantigens used in the authors' laboratories and recent advances in multiplex immunoassays that are suitable for autoantibody detection. Key aspects related to the production of recombinant autoantigens are discussed briefly in this chapter. The construction of recombinant proteins to be used in the detection of autoantibodies should take into consideration the suitability of the construct design and the ease of purification of resulting proteins. Each assay has limitations in terms of determining the sensitivity, specificity, and positive predictive value for the detection of autoantibodies. The chapter focuses on addressable laser bead technology and recent experience with it in a clinical laboratory setting with addressable laser bead immunoassays (ALBIA). In a clinical service laboratory setting an autoantigen panel based on ALBIA was evaluated and compared to the routine diagnostic protocol, which analyzed 870 sequential unselected sera received over a 6-month period. In this study, the sera were submitted primarily by clinicians who were considering a diagnosis of systemic rheumatic disease. Unselected sera from various disease cohorts were also studied to determine if the frequency of autoantibodies as detected by the ALBIA was consistent with the published frequency of autoantibodies. Taken together, there are advantages and challenges that come with the adoption of the ALBA platform to detect autoantibodies. There are now several ALBIA kits on the market that detect eight or more autoantibodies relevant to systemic rheumatic diseases." @default.
- W1417369868 created "2016-06-24" @default.
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- W1417369868 date "2006-01-01" @default.
- W1417369868 modified "2023-09-24" @default.
- W1417369868 title "Detection of Autoantibodies by Using Immobilized Natural and Recombinant Autoantigens" @default.
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- W1417369868 doi "https://doi.org/10.1128/9781555815905.ch114" @default.
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