FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1417385986> ?p ?o ?g. }

• W1417385986 endingPage "53" @default.
• W1417385986 startingPage "45" @default.
• W1417385986 abstract "The size and arrangement of stromal collagen fibrils (CFs) influence the optical properties of the cornea and hence its function. The spatial arrangement of the collagen is still questionable in relation to the diameter of collagen fibril. In the present study, we introduce a new parameter, edge-fibrillar distance (EFD) to measure how two collagen fibrils are spaced with respect to their closest edges and their spatial distribution through normalized standard deviation of EFD (NSDEFD) accessed through the application of two commercially available multipurpose solutions (MPS): ReNu and Hippia. The corneal buttons were soaked separately in ReNu and Hippia MPS for five hours, fixed overnight in 2.5% glutaraldehyde containing cuprolinic blue and processed for transmission electron microscopy. The electron micrographs were processed using ImageJ user-coded plugin. Statistical analysis was performed to compare the image processed equivalent diameter (ED), inter-fibrillar distance (IFD), and EFD of the CFs of treated versus normal corneas. The ReNu-soaked cornea resulted in partly degenerated epithelium with loose hemidesmosomes and Bowman's collagen. In contrast, the epithelium of the cornea soaked in Hippia was degenerated or lost but showed closely packed Bowman's collagen. Soaking the corneas in both MPS caused a statistically significant decrease in the anterior collagen fibril, ED and a significant change in IFD, and EFD than those of the untreated corneas (p<0.05, for all comparisons). The introduction of EFD measurement in the study directly provided a sense of gap between periphery of the collagen bundles, their spatial distribution; and in combination with ED, they showed how the corneal collagen bundles are spaced in relation to their diameters. The spatial distribution parameter NSDEFD indicated that ReNu treated cornea fibrils were uniformly distributed spatially, followed by normal and Hippia. The EFD measurement with relatively lower standard deviation and NSDEFD, a characteristic of uniform CFs distribution, can be an additional parameter used in evaluating collagen organization and accessing the effects of various treatments on corneal health and transparency." @default.
• W1417385986 created "2016-06-24" @default.
• W1417385986 creator A5017894280 @default.
• W1417385986 creator A5037465969 @default.
• W1417385986 creator A5044027209 @default.
• W1417385986 creator A5071526568 @default.
• W1417385986 creator A5075675766 @default.
• W1417385986 date "2015-11-01" @default.
• W1417385986 modified "2023-09-25" @default.
• W1417385986 title "A new method of detecting changes in corneal health in response to toxic insults" @default.
• W1417385986 cites W1968723525 @default.
• W1417385986 cites W1978381123 @default.
• W1417385986 cites W1983059590 @default.
• W1417385986 cites W1983529367 @default.
• W1417385986 cites W1992578566 @default.
• W1417385986 cites W2002073087 @default.
• W1417385986 cites W2009539626 @default.
• W1417385986 cites W2033457306 @default.
• W1417385986 cites W2034333635 @default.
• W1417385986 cites W2036703203 @default.
• W1417385986 cites W2036895638 @default.
• W1417385986 cites W2039016753 @default.
• W1417385986 cites W2040357624 @default.
• W1417385986 cites W2040913012 @default.
• W1417385986 cites W2076352926 @default.
• W1417385986 cites W2080438414 @default.
• W1417385986 cites W2080873175 @default.
• W1417385986 cites W2081240810 @default.
• W1417385986 cites W2087986662 @default.
• W1417385986 cites W2090830406 @default.
• W1417385986 cites W2131648410 @default.
• W1417385986 cites W221947081 @default.
• W1417385986 doi "https://doi.org/10.1016/j.micron.2015.07.007" @default.
• W1417385986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26312735" @default.
• W1417385986 hasPublicationYear "2015" @default.
• W1417385986 type Work @default.
• W1417385986 sameAs 1417385986 @default.
• W1417385986 citedByCount "2" @default.
• W1417385986 countsByYear W14173859862018 @default.
• W1417385986 countsByYear W14173859862022 @default.
• W1417385986 crossrefType "journal-article" @default.
• W1417385986 hasAuthorship W1417385986A5017894280 @default.
• W1417385986 hasAuthorship W1417385986A5037465969 @default.
• W1417385986 hasAuthorship W1417385986A5044027209 @default.
• W1417385986 hasAuthorship W1417385986A5071526568 @default.
• W1417385986 hasAuthorship W1417385986A5075675766 @default.
• W1417385986 hasBestOaLocation W14173859862 @default.
• W1417385986 hasConcept C105702510 @default.
• W1417385986 hasConcept C118487528 @default.
• W1417385986 hasConcept C12554922 @default.
• W1417385986 hasConcept C136229726 @default.
• W1417385986 hasConcept C147075424 @default.
• W1417385986 hasConcept C185592680 @default.
• W1417385986 hasConcept C27523624 @default.
• W1417385986 hasConcept C2776193487 @default.
• W1417385986 hasConcept C2776882836 @default.
• W1417385986 hasConcept C2779257441 @default.
• W1417385986 hasConcept C3019161014 @default.
• W1417385986 hasConcept C71924100 @default.
• W1417385986 hasConcept C86803240 @default.
• W1417385986 hasConceptScore W1417385986C105702510 @default.
• W1417385986 hasConceptScore W1417385986C118487528 @default.
• W1417385986 hasConceptScore W1417385986C12554922 @default.
• W1417385986 hasConceptScore W1417385986C136229726 @default.
• W1417385986 hasConceptScore W1417385986C147075424 @default.
• W1417385986 hasConceptScore W1417385986C185592680 @default.
• W1417385986 hasConceptScore W1417385986C27523624 @default.
• W1417385986 hasConceptScore W1417385986C2776193487 @default.
• W1417385986 hasConceptScore W1417385986C2776882836 @default.
• W1417385986 hasConceptScore W1417385986C2779257441 @default.
• W1417385986 hasConceptScore W1417385986C3019161014 @default.
• W1417385986 hasConceptScore W1417385986C71924100 @default.
• W1417385986 hasConceptScore W1417385986C86803240 @default.
• W1417385986 hasLocation W14173859861 @default.
• W1417385986 hasLocation W14173859862 @default.
• W1417385986 hasLocation W14173859863 @default.
• W1417385986 hasOpenAccess W1417385986 @default.
• W1417385986 hasPrimaryLocation W14173859861 @default.
• W1417385986 hasRelatedWork W1417385986 @default.
• W1417385986 hasRelatedWork W17693391 @default.
• W1417385986 hasRelatedWork W196823532 @default.
• W1417385986 hasRelatedWork W2010382429 @default.
• W1417385986 hasRelatedWork W2017767113 @default.
• W1417385986 hasRelatedWork W2082235629 @default.
• W1417385986 hasRelatedWork W2094783777 @default.
• W1417385986 hasRelatedWork W2095516478 @default.
• W1417385986 hasRelatedWork W2256608549 @default.
• W1417385986 hasRelatedWork W3118184479 @default.
• W1417385986 hasVolume "78" @default.
• W1417385986 isParatext "false" @default.
• W1417385986 isRetracted "false" @default.
• W1417385986 magId "1417385986" @default.
• W1417385986 workType "article" @default.