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- W1417416682 abstract "Publisher Summary Animals receiving increasing amounts of potassium in their diet become resistant to loads of potassium that would normally be lethal in unadapted animals. Such animals excrete large amounts of potassium even when not challenged by acute potassium loads and have an enhanced ability to excrete a sudden challenge of excessive potassium. This enhanced excretion occurs because both the kidney and the gut respond to such potassium adaptation with an enhanced ability to secrete potassium in the urine and the stool. Stereologic techniques allow for morphometric quantitation of three-dimensional objects through the analysis of two-dimensional electron micrographs; however, these techniques require the sampling of cells from individual animals and from groups of animals in different physiologic states. Striking differences were found between the cells of the proximal and distal colon; the proximal colon absorbs more sodium and has a greater passive permeability and a lower transepithelial potential than the distal colon. Potassium adaptation occurs in many organ systems, and in the kidney functional and biochemical changes, similar to those of the colon, occur in the distal tubule. The physiological and biochemical changes induced by alterations in the ionic environment or through hormonal mediation are accompanied by striking structural changes reflected in an increase in the basolateral membrane surface. Membrane changes are associated with changes in potassium intake, glucocorticoid levels, and mineralocorticoid levels; however, these observations lead to yet another area of speculation in relation to the mechanism of induction of these membrane changes." @default.
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- W1417416682 date "1980-01-01" @default.
- W1417416682 modified "2023-09-27" @default.
- W1417416682 title "Chapter 10 Changes in Cell Membrane Surfaces Associated with Alterations of Transepithelial Ion Movement" @default.
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- W1417416682 doi "https://doi.org/10.1016/s0070-2161(08)60278-6" @default.
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