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- W1417508340 abstract "This chapter focuses on the interaction of the tripeptide pyroglutamyl-histidyl-proline amide (thyrotropin-releasing hormone) with brain norepinephrine metabolism. The ability of the thyrotropinreleasing hormone is to modify the final step in norepinephrine biosynthesis, is assessed in vivo and in vitro. A rapidly expanding body of information has implicated several polypeptides as potent regulators of anterior pituitary function. These compounds are thought to be synthesized within specialized nerve cells in the hypothalamus, and exert their effects by being released into the hypothalamo-hypophyseal portal system and either stimulating or inhibiting the release of a particular tropic hormone by specific anterior pituitary cells. Assessment of norepinephrine formation in vivo in hypothyroid rats, where levels of endogenous pyroglutamyl-histidyl-proline amide are low, revealed a marked increase compared to control (euthyroid) rats; these effects, again, were confined to hindbrain regions. Thus, microgram quantities of the tripeptide pyroglutamyl-histidyl-proline amide (thyrotropin-releasing hormone, TRH) given to man result in a rapid stimulation of thyrotropin secretion followed by a more prolonged increase in circulating thyroid hormone concentration." @default.
- W1417508340 created "2016-06-24" @default.
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- W1417508340 date "1975-01-01" @default.
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- W1417508340 title "Interaction of the Tripeptide Pyroglutamyl-Histidyl-Proline Amide (Thyrotropin-Releasing Hormone) with Brain Norepinephrine Metabolism: Evidence for an Extrahypophyseal Action of TRH on Central Nervous System Function" @default.
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- W1417508340 doi "https://doi.org/10.1016/s0079-6123(08)63640-7" @default.
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