FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1417694865> ?p ?o ?g. }

• W1417694865 endingPage "11" @default.
• W1417694865 startingPage "1" @default.
• W1417694865 abstract "One big challenge with active targeting of nanocarriers is non-specific binding between targeting molecules and non-target moieties expressed on non-cancerous cells, which leads to non-specific uptake of nanocarriers by non-cancerous cells. Here, we propose a novel Trojan-horse targeting strategy to hide or expose the targeting molecules of nanocarriers on-demand. The non-specific uptake by non-cancerous cells can be reduced because the targeting molecules are hidden in hydrophilic polymers. The nanocarriers are still actively targetable to cancer cells because the targeting molecules can be exposed on-demand at tumor regions. Typically, Fe3O4 nanocrystals (FN) as magnetic resonance imaging (MRI) contrast agents were encapsulated into albumin nanoparticles (AN), and then folic acid (FA) and pH-sensitive polymers (PP) were grafted onto the surface of AN-FN to construct PP-FA-AN-FN nanoparticles. Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), transmission electron microscope (TEM) and gel permeation chromatography (GPC) results confirm successful construction of PP-FA-AN-FN. According to difference of nanoparticle-cellular uptake between pH 7.4 and 5.5, the weight ratio of conjugated PP to nanoparticle FA-AN-FN (i.e. graft density) and the molecular weight of PP (i.e. graft length) are optimized to be 1.32 and 5.7 kDa, respectively. In vitro studies confirm that the PP can hide ligand FA to prevent it from binding to cells with FRα at pH 7.4 and shrink to expose FA at pH 5.5. In vivo studies demonstrate that our Trojan-horse targeting strategy can reduce the non-specific uptake of the PP-FA-AN-FN by non-cancerous cells. Therefore, our PP-FA-AN-FN might be used as an accurately targeted MRI contrast agent." @default.
• W1417694865 created "2016-06-24" @default.
• W1417694865 creator A5021213624 @default.
• W1417694865 creator A5021734365 @default.
• W1417694865 creator A5034875574 @default.
• W1417694865 creator A5042254280 @default.
• W1417694865 creator A5045719320 @default.
• W1417694865 creator A5056376298 @default.
• W1417694865 creator A5077675757 @default.
• W1417694865 date "2015-11-01" @default.
• W1417694865 modified "2023-10-13" @default.
• W1417694865 title "A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells" @default.
• W1417694865 cites W1967549039 @default.
• W1417694865 cites W1970305621 @default.
• W1417694865 cites W1970950205 @default.
• W1417694865 cites W1977824093 @default.
• W1417694865 cites W1978584972 @default.
• W1417694865 cites W1986931897 @default.
• W1417694865 cites W2003726865 @default.
• W1417694865 cites W2012714389 @default.
• W1417694865 cites W2013001565 @default.
• W1417694865 cites W2019470443 @default.
• W1417694865 cites W2021651355 @default.
• W1417694865 cites W2024985194 @default.
• W1417694865 cites W2029490817 @default.
• W1417694865 cites W2029983315 @default.
• W1417694865 cites W2032760352 @default.
• W1417694865 cites W2035558311 @default.
• W1417694865 cites W2038235273 @default.
• W1417694865 cites W2039695780 @default.
• W1417694865 cites W2042568159 @default.
• W1417694865 cites W2050970597 @default.
• W1417694865 cites W2052067429 @default.
• W1417694865 cites W2055158879 @default.
• W1417694865 cites W2058104225 @default.
• W1417694865 cites W2059246878 @default.
• W1417694865 cites W2076870694 @default.
• W1417694865 cites W2088536552 @default.
• W1417694865 cites W2092666165 @default.
• W1417694865 cites W2093527470 @default.
• W1417694865 cites W2097105120 @default.
• W1417694865 cites W2097631047 @default.
• W1417694865 cites W2118271807 @default.
• W1417694865 cites W2138798362 @default.
• W1417694865 cites W2157804294 @default.
• W1417694865 cites W2169187623 @default.
• W1417694865 cites W7868614 @default.
• W1417694865 doi "https://doi.org/10.1016/j.biomaterials.2015.08.022" @default.
• W1417694865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26295434" @default.
• W1417694865 hasPublicationYear "2015" @default.
• W1417694865 type Work @default.
• W1417694865 sameAs 1417694865 @default.
• W1417694865 citedByCount "49" @default.
• W1417694865 countsByYear W14176948652016 @default.
• W1417694865 countsByYear W14176948652017 @default.
• W1417694865 countsByYear W14176948652018 @default.
• W1417694865 countsByYear W14176948652019 @default.
• W1417694865 countsByYear W14176948652020 @default.
• W1417694865 countsByYear W14176948652021 @default.
• W1417694865 countsByYear W14176948652022 @default.
• W1417694865 countsByYear W14176948652023 @default.
• W1417694865 crossrefType "journal-article" @default.
• W1417694865 hasAuthorship W1417694865A5021213624 @default.
• W1417694865 hasAuthorship W1417694865A5021734365 @default.
• W1417694865 hasAuthorship W1417694865A5034875574 @default.
• W1417694865 hasAuthorship W1417694865A5042254280 @default.
• W1417694865 hasAuthorship W1417694865A5045719320 @default.
• W1417694865 hasAuthorship W1417694865A5056376298 @default.
• W1417694865 hasAuthorship W1417694865A5077675757 @default.
• W1417694865 hasConcept C12554922 @default.
• W1417694865 hasConcept C14631669 @default.
• W1417694865 hasConcept C15083742 @default.
• W1417694865 hasConcept C155672457 @default.
• W1417694865 hasConcept C171250308 @default.
• W1417694865 hasConcept C18150654 @default.
• W1417694865 hasConcept C185592680 @default.
• W1417694865 hasConcept C192562407 @default.
• W1417694865 hasConcept C86803240 @default.
• W1417694865 hasConceptScore W1417694865C12554922 @default.
• W1417694865 hasConceptScore W1417694865C14631669 @default.
• W1417694865 hasConceptScore W1417694865C15083742 @default.
• W1417694865 hasConceptScore W1417694865C155672457 @default.
• W1417694865 hasConceptScore W1417694865C171250308 @default.
• W1417694865 hasConceptScore W1417694865C18150654 @default.
• W1417694865 hasConceptScore W1417694865C185592680 @default.
• W1417694865 hasConceptScore W1417694865C192562407 @default.
• W1417694865 hasConceptScore W1417694865C86803240 @default.
• W1417694865 hasFunder F4320321001 @default.
• W1417694865 hasFunder F4320322120 @default.
• W1417694865 hasLocation W14176948651 @default.
• W1417694865 hasLocation W14176948652 @default.
• W1417694865 hasOpenAccess W1417694865 @default.
• W1417694865 hasPrimaryLocation W14176948651 @default.
• W1417694865 hasRelatedWork W2727899900 @default.
• W1417694865 hasRelatedWork W2759215993 @default.
• W1417694865 hasRelatedWork W2895282589 @default.
• W1417694865 hasRelatedWork W2902445771 @default.
• W1417694865 hasRelatedWork W3126369458 @default.

• next