Matches in SemOpenAlex for { <https://semopenalex.org/work/W141781890> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W141781890 endingPage "94.12" @default.
- W141781890 startingPage "94.12" @default.
- W141781890 abstract "Abstract Remote ischemic preconditioning(RIPC) consists of short periods of ischemia followed by reperfusion, which induces protective anti-inflammatory effect on distance organs. Studies have shown that inflammatory parameters such as leukocyte migration are significantly reduced in pre-conditioned animals.However, the mechanism involved in this effect is not yet well established. This study evaluated if NO and CO is mediating the anti-inflammatory activity of RIPC.RIPC model is based on turnstile in right leg of a mouse for 10 minutes followed by 30 of reperfusion. Participation of NO and CO was investigated using inhibitors of iNOS (1400W; 3mg/kg or Aminoguanide; 50mg/kg) and HO-1 (ZnPPIX;10mg/kg) as pre-treatment 30 minutes before RIPC. Afterwards, inflammatory reaction was induced by intraperitoneal administration of Carragenin(500µg/cav).Four hours after the peritoneal cavities were washed with saline and number of migrated leukocytes was evaluated. Chemotaxis ability of neutrophils obtained from mice under RIPC treated or not with the inhibitors was analyzed in Boyden Chamber. Expression of CXCR2 and GRK2 in neutrophils was determined by flow cytometry and immunofluorescence, respectively.CO and NO inhibitors prevented the inhibitory effect of RIPC upon Cg-induced neutrophil migration into peritoneal cavity of animals, as well as, upon KC induced neutrophils chemotaxis in Boyden Chamber. The reduction of neutrophil chemotaxis by RICP correlated with CXCR2 internalization and increase of GRK2 expression in the neutrophils.CO and NO production prevented these effects of RICP.Thus,inhibitors of HO-1/CO and NOSi/NO pathways seem to mediate the anti-inflammatory effect of RICP." @default.
- W141781890 created "2016-06-24" @default.
- W141781890 creator A5020132336 @default.
- W141781890 creator A5031690868 @default.
- W141781890 creator A5042279880 @default.
- W141781890 creator A5058892165 @default.
- W141781890 creator A5080243666 @default.
- W141781890 date "2009-04-01" @default.
- W141781890 modified "2023-10-11" @default.
- W141781890 title "Nitric Oxide and Carbon Monoxide mediate the anti-inflammatory effects of Remote Ischemic Preconditioning (RIPC) (94.12)" @default.
- W141781890 doi "https://doi.org/10.4049/jimmunol.182.supp.94.12" @default.
- W141781890 hasPublicationYear "2009" @default.
- W141781890 type Work @default.
- W141781890 sameAs 141781890 @default.
- W141781890 citedByCount "1" @default.
- W141781890 crossrefType "journal-article" @default.
- W141781890 hasAuthorship W141781890A5020132336 @default.
- W141781890 hasAuthorship W141781890A5031690868 @default.
- W141781890 hasAuthorship W141781890A5042279880 @default.
- W141781890 hasAuthorship W141781890A5058892165 @default.
- W141781890 hasAuthorship W141781890A5080243666 @default.
- W141781890 hasConcept C105702510 @default.
- W141781890 hasConcept C126322002 @default.
- W141781890 hasConcept C13373296 @default.
- W141781890 hasConcept C170493617 @default.
- W141781890 hasConcept C178790620 @default.
- W141781890 hasConcept C185592680 @default.
- W141781890 hasConcept C203014093 @default.
- W141781890 hasConcept C2776914184 @default.
- W141781890 hasConcept C2777397205 @default.
- W141781890 hasConcept C2777622882 @default.
- W141781890 hasConcept C2778536324 @default.
- W141781890 hasConcept C2779311647 @default.
- W141781890 hasConcept C42219234 @default.
- W141781890 hasConcept C519581460 @default.
- W141781890 hasConcept C54166955 @default.
- W141781890 hasConcept C541997718 @default.
- W141781890 hasConcept C553184892 @default.
- W141781890 hasConcept C55493867 @default.
- W141781890 hasConcept C71924100 @default.
- W141781890 hasConcept C98274493 @default.
- W141781890 hasConceptScore W141781890C105702510 @default.
- W141781890 hasConceptScore W141781890C126322002 @default.
- W141781890 hasConceptScore W141781890C13373296 @default.
- W141781890 hasConceptScore W141781890C170493617 @default.
- W141781890 hasConceptScore W141781890C178790620 @default.
- W141781890 hasConceptScore W141781890C185592680 @default.
- W141781890 hasConceptScore W141781890C203014093 @default.
- W141781890 hasConceptScore W141781890C2776914184 @default.
- W141781890 hasConceptScore W141781890C2777397205 @default.
- W141781890 hasConceptScore W141781890C2777622882 @default.
- W141781890 hasConceptScore W141781890C2778536324 @default.
- W141781890 hasConceptScore W141781890C2779311647 @default.
- W141781890 hasConceptScore W141781890C42219234 @default.
- W141781890 hasConceptScore W141781890C519581460 @default.
- W141781890 hasConceptScore W141781890C54166955 @default.
- W141781890 hasConceptScore W141781890C541997718 @default.
- W141781890 hasConceptScore W141781890C553184892 @default.
- W141781890 hasConceptScore W141781890C55493867 @default.
- W141781890 hasConceptScore W141781890C71924100 @default.
- W141781890 hasConceptScore W141781890C98274493 @default.
- W141781890 hasIssue "1_Supplement" @default.
- W141781890 hasLocation W1417818901 @default.
- W141781890 hasOpenAccess W141781890 @default.
- W141781890 hasPrimaryLocation W1417818901 @default.
- W141781890 hasRelatedWork W1978327381 @default.
- W141781890 hasRelatedWork W1986835936 @default.
- W141781890 hasRelatedWork W1990842025 @default.
- W141781890 hasRelatedWork W2051938538 @default.
- W141781890 hasRelatedWork W2055462428 @default.
- W141781890 hasRelatedWork W2061708338 @default.
- W141781890 hasRelatedWork W2098776639 @default.
- W141781890 hasRelatedWork W2364217646 @default.
- W141781890 hasRelatedWork W2373495850 @default.
- W141781890 hasRelatedWork W2388981420 @default.
- W141781890 hasVolume "182" @default.
- W141781890 isParatext "false" @default.
- W141781890 isRetracted "false" @default.
- W141781890 magId "141781890" @default.
- W141781890 workType "article" @default.